H2BC12 - H2B clustered histone 12 Gene

Homo sapiens

Also known as H2BK; H2B/S; H2BFT; H2BFAiii; HIST1H2BK

Gene ID: 85236 | Gene type: protein coding

About H2BC12

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,138,293-27,146,858 (from NCBI)

This gene has 1 transcript (splice variant), 164 orthologues and 21 paralogues. Ubiquitous expression in prostate (RPKM 42.3), testis (RPKM 29.8) and 25 other tissues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with Antibacterial and Antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

H2BC12 Products(2)

mRNA	Protein	Name
NM_001312653.2	NP_001299582.1	histone H2B type 1-K
NM_080593.2	NP_542160.1	histone H2B type 1-K

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31759698	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	12860195	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12860195	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	15019208	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	12860195	GOA
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	12860195	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	15019208	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12860195	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16319397	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H2BC12 Protein Structure

Histone

0
100
126 a.a.

Protein Preferred Names

Protein Names

histone H2B type 1-K

H2B K

H2BC12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	H2BC12	O60814	LANA1	Human herpesvirus 8	Q9QR71	Crosslink	31759698
Intra	H2BC12	O60814	SMARCB1	Homo sapiens	Q12824	Competition Binding	31759698
Intra	H2BC12	O60814	SMARCB1	Homo sapiens	Q12824	Crosslink	31759698

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05960	H2BC12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	H2BC12	MGD	MGI:2448399
Macaca mulatta	H2BC12	VGNC	VGNC:109709
Rattus norvegicus	H2BC12	RGD	RGD:1593016

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