Hrh3 - histamine receptor H3 Gene

Rattus norvegicus

Gene ID: 85268 | Gene type: protein coding

About Hrh3

Primary_assembly 3: 167,191,558-167,196,642 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 117 orthologues, 35 paralogues and is associated with 13 phenotypes. Biased expression in Brain (RPKM 5.6), Thymus (RPKM 18.3) and 4 other tissues.

Summary

This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]

Hrh3 Products(8)

mRNA	Protein	Name
NM_001270567.1	NP_001257496.1	histamine H3 receptor isoform H3E
NM_001270570.1	NP_001257499.1	histamine H3 receptor isoform 8
NM_053506.2	NP_445958.1	histamine H3 receptor isoform H3A
NM_001270564.1	NP_001257493.1	histamine H3 receptor isoform H3B
NM_001270565.1	NP_001257494.1	histamine H3 receptor isoform H3C
NM_001270569.1	NP_001257498.1	histamine H3 receptor isoform 7
NM_001270566.1	NP_001257495.1	histamine H3 receptor isoform H3D
NM_001270568.1	NP_001257497.1	histamine H3 receptor isoform H3F

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables amine binding	IPI IPI: Inferred from physical interaction	10869375	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	10869375	RGD
enables organic cyclic compound binding	IMP IMP: Inferred from mutant phenotype	11090094	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP metabolic process	IDA IDA: Inferred from direct assay	11130725	RGD
involved in cognition	IMP IMP: Inferred from mutant phenotype	17327487	RGD
involved in drinking behavior	IMP IMP: Inferred from mutant phenotype	17327487	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	17189541	RGD
involved in learning	IMP IMP: Inferred from mutant phenotype	17327487	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	15695163	RGD
involved in negative regulation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	10869375	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	9050021	RGD
involved in negative regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	17350613	RGD
involved in negative regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	17027043	RGD
involved in negative regulation of serotonin secretion	IMP IMP: Inferred from mutant phenotype	15470136	RGD
involved in positive regulation of arachidonate secretion	IDA IDA: Inferred from direct assay	11130725	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	17350613	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16682020	RGD
involved in regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	15076218	RGD
involved in response to forskolin	IDA IDA: Inferred from direct assay	11130725	RGD
involved in response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	16316645	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hrh3 Protein Structure

7tm_GPCRs

0
100
200
300
400
497 a.a.

Protein Preferred Names

Protein Names

histamine H3 receptor

H3R

HH3R

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06365	HRH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06366	Hrh3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06367	Hrh3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hrh3	NCBI	NCBI:11255

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