DGKD - diacylglycerol kinase delta Gene

Homo sapiens

Also known as dgkd-2; DGKdelta; DGK-delta

Gene ID: 8527 | Gene type: protein coding

About DGKD

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,354,494-233,472,098 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 213 orthologues and 9 paralogues. Broad expression in stomach (RPKM 11.9), bone marrow (RPKM 9.9) and 23 other tissues.

Summary

This gene encodes a cytoplasmic Enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

DGKD Products(3)

mRNA	Protein	Name
NM_001377259.1	NP_001364188.1	diacylglycerol kinase delta isoform 3
NM_003648.3	NP_003639.2	diacylglycerol kinase delta isoform 1
NM_152879.3	NP_690618.2	diacylglycerol kinase delta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: Inferred from direct assay	12200442	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	12084710	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12200442	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	12810723	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12200442	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12200442	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12200442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in diacylglycerol metabolic process	IDA IDA: Inferred from direct assay	12200442	GOA
involved in lipid phosphorylation	IDA IDA: Inferred from direct assay	17880279	GOA
involved in phosphatidic acid biosynthetic process	IDA IDA: Inferred from direct assay	17880279	GOA
involved in positive regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	17880279	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	17880279	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12200442	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12200442	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12084710	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12084710	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKD Protein Structure

C1_1

DAGK_cat

DAGK_acc

SAM_2

0
200
400
600
800
1000
1214 a.a.

Protein Preferred Names

Protein Names

diacylglycerol kinase delta

DAG kinase delta

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03717	DGKD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DGKD	VGNC	VGNC:39917
Macaca mulatta	DGKD	VGNC	VGNC:71783
Bos taurus	DGKD	VGNC	VGNC:28026
Rattus norvegicus	DGKD	RGD	RGD:1563309
Mus musculus	DGKD	MGD	MGI:2138334
Felis catus	DGKD	VGNC	VGNC:61459

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