SYDE1 - synapse defective Rho GTPase homolog 1 Gene

Homo sapiens

Also known as 7h3; SYD1

Gene ID: 85360 | Gene type: protein coding

About SYDE1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,107,401-15,114,974 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 9.3), placenta (RPKM 9.2) and 23 other tissues.

Summary

The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]

SYDE1 Products(2)

mRNA	Protein	Name
NM_001300910.2	NP_001287839.1	rho GTPase-activating protein SYDE1 isoform 2
NM_033025.6	NP_149014.3	rho GTPase-activating protein SYDE1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	27917469	GOA
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	27917469	GOA
enables GTPase regulator activity	IDA IDA: Inferred from direct assay	27917469	GOA
enables GTPase regulator activity	IMP IMP: Inferred from mutant phenotype	27917469	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IDA IDA: Inferred from direct assay	27917469	GOA
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	27917469	GOA
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	27917469	GOA
involved in positive regulation of trophoblast cell migration	IMP IMP: Inferred from mutant phenotype	27917469	GOA
involved in regulation of cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27917469	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYDE1 Protein Structure

RhoGAP

0
200
400
600
735 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein SYDE1

protein syd-1 homolog 1

Related Diseases

Diseases

Alias

Autosomal Dominant Wolfram Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14073	SYDE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SYDE1	RGD	RGD:1305857
Canis familiaris	SYDE1	VGNC	VGNC:47020
Bos taurus	SYDE1	VGNC	VGNC:35510
Mus musculus	SYDE1	MGD	MGI:1918959
Felis catus	SYDE1	VGNC	VGNC:80729

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