BCAS1 - brain enriched myelin associated protein 1 Gene

Homo sapiens

Also known as AIBC1; NABC1; PMES-2

Gene ID: 8537 | Gene type: protein coding

About BCAS1

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:53,943,541-54,070,594 (from NCBI)

This gene has 11 transcripts (splice variants) and 125 orthologues. Biased expression in stomach (RPKM 58.5), colon (RPKM 41.1) and 7 other tissues.

Summary

This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast Cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast Cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]

BCAS1 Products(7)

mRNA	Protein	Name
NM_001316361.3	NP_001303290.1	breast carcinoma-amplified sequence 1 isoform 2
NM_001323347.2	NP_001310276.1	breast carcinoma-amplified sequence 1 isoform 2
NM_001366295.2	NP_001353224.1	breast carcinoma-amplified sequence 1 isoform 3
NM_001366296.2	NP_001353225.1	breast carcinoma-amplified sequence 1 isoform 4
NM_001366297.2	NP_001353226.1	breast carcinoma-amplified sequence 1 isoform 5
NM_001366298.2	NP_001353227.1	breast carcinoma-amplified sequence 1 isoform 6
NM_003657.4	NP_003648.2	breast carcinoma-amplified sequence 1 isoform 1

Protein Preferred Names

Protein Names

breast carcinoma-amplified sequence 1

amplified and overexpressed in breast cancer

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16993	OICR-9429		99.71%	Unkown
HY-RS01399	BCAS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BCAS1	MGD	MGI:1924210
Macaca mulatta	BCAS1	VGNC	VGNC:98871
Rattus norvegicus	BCAS1	RGD	RGD:628644
Felis catus	BCAS1	VGNC	VGNC:98869
Canis familiaris	BCAS1	VGNC	VGNC:98867
Bos taurus	BCAS1	VGNC	VGNC:98868

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