SLC22A16 - solute carrier family 22 member 16 Gene

Homo sapiens

Also known as CT2; OAT6; OCT6; OKB1; FLIPT2; HEL-S-18; dJ261K5.1

Gene ID: 85413 | Gene type: protein coding

About SLC22A16

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,424,687-110,476,613 (from NCBI)

This gene has 8 transcripts (splice variants), 258 orthologues and 22 paralogues. Biased expression in testis (RPKM 7.7) and bone marrow (RPKM 4.9).

Summary

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport Anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

SLC22A16 Products(1)

mRNA	Protein	Name
NM_033125.4	NP_149116.2	solute carrier family 22 member 16

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15963465	GOA
enables carnitine transmembrane transporter activity	IDA IDA: Inferred from direct assay	12089149	GOA
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	12089149	GOA
enables spermidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	20037140	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acid secretion	IDA IDA: Inferred from direct assay	12089149	GOA
involved in carnitine transmembrane transport	IDA IDA: Inferred from direct assay	12089149	GOA
acts upstream of or within carnitine transport	IDA IDA: Inferred from direct assay	12089149	GOA
involved in carnitine transport	IDA IDA: Inferred from direct assay	12089149	GOA
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	12089149	GOA
acts upstream of or within organic cation transport	IDA IDA: Inferred from direct assay	15963465	GOA
involved in organic cation transport	IDA IDA: Inferred from direct assay	12089149	GOA
involved in single fertilization	IMP IMP: Inferred from mutant phenotype	12089149	GOA
involved in spermidine transmembrane transport	IDA IDA: Inferred from direct assay	20037140	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	12089149	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12089149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A16 Protein Structure

Sugar_tr

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 16

WUGSC:RG331P03.1

Related Diseases

Diseases

Alias

Clear Cell Adenocarcinoma

Mesonephroma	Water-Clear Cell Adenocarcinoma
Adenocarcinoma, Clear Cell	Malignant Mesonephroma
Mesonephroid Clear Cell Carcinoma	Mesonephroma, Malignant
Water-Clear Cell Carcinoma	Wolffian Duct Neoplasm
Adenocarcinoma Clear Cell	Mesonephric Tumor

Rhizomelic Chondrodysplasia Punctata, Type 3

Rhizomelic Chondrodysplasia Punctata Type 3	RCDP3
Alkyldihydroxyacetonephosphate Synthase Deficiency	Alkylglycerone-Phosphate Synthase Deficiency
Agps Deficiency	Rhizomelic Chondrodysplasia Punctata 3
Chondrodysplasia Punctata, Rhizomelic, Type 3

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13069	SLC22A16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC22A16	VGNC	VGNC:65241
Rattus norvegicus	SLC22A16	RGD	RGD:1592810
Macaca mulatta	SLC22A16	VGNC	VGNC:77527
Bos taurus	SLC22A16	VGNC	VGNC:34724
Mus musculus	SLC22A16	MGD	MGI:1918090
Canis familiaris	SLC22A16	VGNC	VGNC:46277

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