2. Gene
  3. RHPN2 - rhophilin Rho GTPase binding protein 2 Gene

RHPN2 - rhophilin Rho GTPase binding protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RHOBP; P76RBE

Gene ID: 85415 | Gene type: protein coding

About RHPN2

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:32,978,592-33,064,888 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 1 paralogue. Broad expression in colon (RPKM 18.4), prostate (RPKM 16.3) and 16 other tissues.

Summary

This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin Cytoskeleton. [provided by RefSeq, Apr 2009]

RHPN2 Products(1)

mRNA Protein Name
NM_033103.5 NP_149094.3 rhophilin-2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
25071083 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
25071083 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHPN2 Protein Structure

HR1

HR1: Hr1 repeat (39 - 103)

BRO1

BRO1: BRO1-like domain (111 - 512)

  • 0
  • 200
  • 400
  • 600
  • 686 a.a.
Protein Preferred Names Protein Names

rhophilin-2

76 kDa RhoB effector protein

Related Diseases

Diseases Alias
Hereditary Mixed Polyposis Syndrome

Hmps
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11962 RHPN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RHPN2 VGNC VGNC:52240
Canis familiaris RHPN2 VGNC VGNC:53760
Mus musculus RHPN2 MGD MGI:1289234
Rattus norvegicus RHPN2 RGD RGD:1308366