Prkcq - protein kinase C, theta Gene

Rattus norvegicus

Also known as Pkcq

Gene ID: 85420 | Gene type: protein coding

About Prkcq

Primary_assembly 17: 67,246,394-67,378,704 reverse strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 204 orthologues, 5 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 276.), Muscle (RPKM 269.6) and 7 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cellular component biogenesis; positive regulation of protein transport; and response to glucose. Located in several cellular components, including neuromuscular junction; nucleus; and sarcolemma. Biomarker of hyperinsulinism and prostate adenocarcinoma. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcq Products(2)

mRNA	Protein	Name
NM_001276721.1	NP_001263650.1	protein kinase C theta type
NM_001276721.1	NP_001263650.1	protein kinase C theta type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11698413	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12697665	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12697665	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	10944456	RGD
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	9353339	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	12697665	RGD
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	11095914	RGD
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	9353339	RGD
involved in regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	9353339	RGD
involved in regulation of vasoconstriction	IEP IEP: Inferred from expression pattern	16951045	RGD
involved in respiratory burst	IEP IEP: Inferred from expression pattern	10218646	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	11914741	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15994856	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	7755564	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11404218	RGD
involved in tissue regeneration	IEP IEP: Inferred from expression pattern	12007632	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuromuscular junction	IDA IDA: Inferred from direct assay	7738116	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	7738116	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcq Protein Structure

C1_nPKC_theta-like_rpt1

C1_nPKC_theta-like_rpt2

STKc_nPKC_theta

0
200
400
600
707 a.a.

Protein Preferred Names

Protein Names

protein kinase C theta type

nPKC-theta

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11137	PRKCQ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11138	Prkcq Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11139	Prkcq Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcq	NCBI	NCBI:5588

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