PRKCQ - protein kinase C theta Gene

Homo sapiens

Also known as PRKCT; nPKC-theta

Gene ID: 5588 | Gene type: protein coding

About PRKCQ

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:6,394,097-6,580,646 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 5 paralogues. Broad expression in thyroid (RPKM 4.0), lymph node (RPKM 2.9) and 17 other tissues.

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

PRKCQ Products(9)

mRNA	Protein	Name
NM_001323267.2	NP_001310196.1	protein kinase C theta type isoform 5
NM_001323265.1	NP_001310194.1	protein kinase C theta type isoform 1
NM_006257.5	NP_006248.1	protein kinase C theta type isoform 1
NM_001282645.1	NP_001269574.1	protein kinase C theta type isoform 4
XM_005252496.5	XP_005252553.1	protein kinase C theta type isoform X1
NM_001242413.2	NP_001229342.1	protein kinase C theta type isoform 2
XM_005252497.5	XP_005252554.1	protein kinase C theta type isoform X2
NM_001282644.2	NP_001269573.1	protein kinase C theta type isoform 3
NM_001323266.2	NP_001310195.1	protein kinase C theta type isoform 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	16356856	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10383400	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	34593629	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	24008408	GOA
involved in negative regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11342610	GOA
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15364919	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16356855	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	34593629	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCQ Protein Structure

C1_1

Pkinase

Pkinase_C

0
200
400
600
706 a.a.

Protein Preferred Names

Protein Names

protein kinase C theta type

PRKCQ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKCQ	Q04759	LCK	Homo sapiens	P06239	Anti Tag CoIP	21964608
Intra	PRKCQ	Q04759	MAP4K3	Homo sapiens	Q8IVH8	Pull Down	21983831
Intra	PRKCQ	Q04759	PRKCZ	Homo sapiens	Q05513	Y2H	17588663
Intra	PRKCQ	Q04759	GLRX3	Homo sapiens	O76003	CoIP	10636891
Intra	PRKCQ	Q04759	GLRX3	Homo sapiens	O76003	Pull Down	10636891
Intra	PRKCQ	Q04759	FYN	Homo sapiens	P06241	Protein Kinase Assay	10383400
Intra	PRKCQ	Q04759	FYN	Homo sapiens	P06241	Pull Down	10383400
Intra	PRKCQ	Q04759	FYN	Homo sapiens	P06241	Y2H	10383400
Intra	PRKCQ	Q04759	HSF1	Homo sapiens	Q00613	Anti Bait CoIP	23352416
Cross	PRKCQ	Q04759	Irs1	Rattus norvegicus	P35570	Protein Kinase Assay	23352416

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Ciliary Dyskinesia, Primary, 20

Primary Ciliary Dyskinesia 20	CILD20
Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus
Ics20	Immotile Cilia Syndrome 20
Dyskinesia, Ciliary, Primary, 20

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Enteritis, Granulomatous	Crohn'S Disease Of Colon
Granulomatous Colitis	Colitis, Granulomatous
Crohn'S Enteritis	Enteritis, Regional
Enteritis	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11137	PRKCQ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11138	Prkcq Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11139	Prkcq Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKCQ	MGD	MGI:97601
Felis catus	PRKCQ	VGNC	VGNC:69067
Canis familiaris	PRKCQ	VGNC	VGNC:44983
Rattus norvegicus	PRKCQ	RGD	RGD:620968
Macaca mulatta	PRKCQ	VGNC	VGNC:76416
Bos taurus	PRKCQ	VGNC	VGNC:33334

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