Nox4 - NADPH oxidase 4 Gene

Rattus norvegicus

Gene ID: 85431 | Gene type: protein coding

About Nox4

Primary_assembly 1: 140,901,097-141,077,406 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 149 orthologues, 5 paralogues and is associated with 20 phenotypes. Biased expression in Kidney (RPKM 64.2), Lung (RPKM 75.7) and 1 other tissue.

Summary

Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and positive regulation of stress fiber assembly. Located in several cellular components, including apical plasma membrane; focal adhesion; and perinuclear endoplasmic reticulum. Part of NADPH Oxidase complex. Colocalizes with stress fiber. Used to study hypertension. Biomarker of hypertension and non-alcoholic steatohepatitis. Orthologous to human NOX4 (NADPH Oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Nox4 Products(1)

mRNA	Protein	Name
NM_053524.1	NP_445976.1	NADPH oxidase 4

Nox4 Protein Structure

Ferric_reduct

NOX_Duox_like_FAD_NADP

0
100
200
300
400
500
623 a.a.

Protein Preferred Names

Protein Names

NADPH oxidase 4

kidney oxidase-1	kidney superoxide-producing NADPH oxidase
kox-1

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.45%	Phase 3
HY-120801	APX-115	Inhibitor	99.58%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	98.11%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100111	GLX351322	Inhibitor	99.67%	Unkown
HY-101499	GKT136901	Inhibitor	99.70%	Unkown
HY-152026	NADPH oxidase-IN-1	Inhibitor	99.60%	Unkown
HY-N3239	Mulberrofuran G	Inhibitor	99.84%	Unkown
HY-105946	Hidrosmin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nox4	NCBI	NCBI:50507

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