FCN3 - ficolin 3 Gene

Homo sapiens

Also known as FCNH; HAKA1

Gene ID: 8547 | Gene type: protein coding

About FCN3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,369,110-27,374,824 (from NCBI)

This gene has 6 transcripts (splice variants), 52 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in lung (RPKM 93.2), liver (RPKM 47.7) and 3 other tissues.

Summary

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

FCN3 Products(2)

mRNA	Protein	Name
NM_003665.4	NP_003656.2	ficolin-3 isoform 1 precursor
NM_173452.3	NP_775628.1	ficolin-3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antigen binding	IDA IDA: Inferred from direct assay	22851708	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19109177	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11907111	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in complement activation	IDA IDA: Inferred from direct assay	22851708	GOA
involved in complement activation, lectin pathway	IDA IDA: Inferred from direct assay	11907111	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	22851708	GOA
involved in negative regulation of RNA biosynthetic process	IDA IDA: Inferred from direct assay	22851708	GOA
involved in negative regulation of viral entry into host cell	IMP IMP: Inferred from mutant phenotype	22851708	GOA
involved in positive regulation of opsonization	IDA IDA: Inferred from direct assay	11907111	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	11907111	GOA
involved in recognition of apoptotic cell	IDA IDA: Inferred from direct assay	15804047	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of serine-type endopeptidase complex	IDA IDA: Inferred from direct assay	11907111	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCN3 Protein Structure

Collagen

Fibrinogen_C

0
100
200
299 a.a.

Protein Preferred Names

Protein Names

ficolin-3

H-ficolin

FCN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FCN3	O75636	MASP1	Homo sapiens	P48740-2	GMS	23785123
Intra	FCN3	O75636	MASP1	Homo sapiens	P48740-3	GMS	23785123
Intra	FCN3	O75636	FCN2	Homo sapiens	Q15485	Anti Bait CoIP	32094208
Cross	FCN3	O75636	fbpB	Mycobacterium tuberculosis	P9WQP1	Anti Bait CoIP	27141819

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ficolin 3 Deficiency

Immunodeficiency Due To Ficolin 3 Deficiency	Immunodeficiency Due To Ficolin3 Deficiency
Fcn3 Deficiency	Lcapd3
Lectin Complement Activation Pathway, Defect In, 3	FCN3D
Defect In Lectin Complement Activation Pathway, 3

Rheumatic Heart Disease

Rheumatic Carditis	Rheumatic Congestive Heart Failure
Congestive Rheumatic Heart Failure	Rheumatic Heart Failure
RHD	Rheumatic Fever Inactive Or Quiescent With Heart Disease
Rheumatic Fever Inactive Or Quiescent With Carditis	Organ Rheumatic Heart Disease
Organic Rheumatic Heart Disease	Inactive Rheumatic Heart Disease
Rheumatic Heart	Rheumatic Fever Inactive Or Quiescent With Pancarditis
Rhd - [Rheumatic Heart Disease]	Rheumatic Cardiac Hypertrophy
Rheumatic Fever	Inactive Or Quiescent With Cardiac Hypertrophy
Rheumatic Pancarditis	Inactive Rhd - [Rheumatic Heart Disease]
Rheumatic Nonischaemic Cardiopathy

Rheumatic Fever

Acute Rheumatic Fever	Rhf - Rheumatic Fever
Inflammatory Rheumatism	Active Rheumatic Fever Nos
Acute Active Rheumatic Fever	Subacute Active Rheumatic Fever
Subacute Rheumatic Fever	Active Rheumatic Fever With Unspecified Type Of Heart Involvement
Acute Rheumatic Heart Disease	Active Rheumatic Heart Disease
Acute Organic Rhd - [Rheumatic Heart Disease]	Acute Rhd - [Rheumatic Heart Disease]

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome	Malpuech Facial Clefting Syndrome
Oculopalatoskeletal Syndrome	Carnevale Syndrome
Michels Syndrome	Malpuech-Michels-Mingarelli-Carnevale Syndrome
Carnevale-Krajewska-Fischetto Syndrome	Craniosynostosis With Lid Anomalies
Malpuech Syndrome	Mingarelli Syndrome
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia	Ptosis-Strabismus-Rectus Abdominis Diastasis

3mc Syndrome 2

3MC2	Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Carnevale Syndrome	Carnevale Syndrome, Formerly
Carnevale Krajewska Fischetto Syndrome	3mc Syndrome, Type 2

3mc Syndrome 1

Oculopalatoskeletal Syndrome	3MC1
Craniosynostosis With Lid Anomalies	Michels Syndrome, Formerly
Michels Syndrome	3mc Syndrome, Type 1

Pulmonary Aspergilloma

Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4	AGM4
Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect	B Cell Linker Protein Deficiency
B-Cell Linker Protein Deficiency	Blnk Deficiency
Agammaglobulinemia Autosomal Recessive Due To Blnk Defect	Agammaglobulinemia, Type 4, Autosomal Recessive

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04841	FCN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FCN3	VGNC	VGNC:72630
Rattus norvegicus	FCN3	RGD	RGD:621221

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