SCIN - scinderin Gene

Homo sapiens

Gene ID: 85477 | Gene type: protein coding

About SCIN

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:12,570,720-12,660,182 (from NCBI)

This gene has 10 transcripts (splice variants), 179 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 29.7), kidney (RPKM 29.3) and 11 other tissues.

Summary

SCIN is a CA(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

SCIN Products(2)

mRNA	Protein	Name
NM_001112706.3	NP_001106177.1	scinderin isoform 1
NM_033128.3	NP_149119.1	scinderin isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament capping	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in actin filament severing	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in positive regulation of actin nucleation	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in positive regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in sequestering of actin monomers	IMP IMP: Inferred from mutant phenotype	19666531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCIN Protein Structure

Gelsolin

0
200
400
600
715 a.a.

Protein Preferred Names

Protein Names

scinderin

adseverin

Related Diseases

Diseases

Alias

Ritter'S Disease

Staphylococcal Scalded Skin Syndrome	Pemphigus Neonatorum
Ritter Disease	Dermatitis Exfoliativa Neonatorum
Scalded Skin Syndrome	Toxic Epidermal Necrolysis, Subcorneal Type
Generalized Exfoliative Disease	Ssss
Ssss - [Staphylococcal Scalded Skin Syndrome]

Carbuncle

Carbuncle And Furuncle Of Any Part Of Face Except Eye	Carbuncle And Furuncle Of Buttock
Carbuncle And Furuncle Of Face	Carbuncle And Furuncle Of Foot
Carbuncle And Furuncle Of Gluteal Region	Carbuncle And Furuncle Of Hand
Carbuncle And Furuncle Of Leg Except Foot	Carbuncle And Furuncle Of Neck
Carbuncle And Furuncle Of Trunk	Carbuncle And Furuncle Of Upper Arm And Forearm

Endocardium Disease

Septic Arthritis

Infectious Arthritis	Arthritis, Infectious
Arthritis Septic	Arthritis, Bacterial

Waterhouse-Friderichsen Syndrome

Fatal Pneumococcal Waterhouse-Friderichsen Syndrome	Meningococcal Hemorrhagic Adrenalitis
Waterhouse-Friderichsen Syndrome, Meningococcal	Meningococcal Haemorrhagic Adrenalitis
Meningococcal Adrenal Syndrome	Acute Adrenal Insufficiency With Meningococcal Septicaemia
Adrenal Haemorrhage Syndrome	Waterhouse-Friderichsen Disease
Meningococcal Waterhouse-Friderichsen Syndrome	Haemorrhagic Meningococcal Adrenitis

Commensal Bacterial Infectious Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12512	SCIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCIN	VGNC	VGNC:34339
Felis catus	SCIN	VGNC	VGNC:64914
Mus musculus	SCIN	MGD	MGI:1306794
Macaca mulatta	SCIN	VGNC	VGNC:81562
Rattus norvegicus	SCIN	RGD	RGD:735034
Others	SCIN	NCBI

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