TMEFF1 - transmembrane protein with EGF like and two follistatin like domains 1 Gene

Homo sapiens

Also known as TR-1; H7365; C9orf2; CT120.1

Gene ID: 8577 | Gene type: protein coding

About TMEFF1

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:100,473,149-100,577,636 (from NCBI)

This gene has 1 transcript (splice variant), 126 orthologues and 27 paralogues. Biased expression in brain (RPKM 20.3), testis (RPKM 3.9) and 6 other tissues.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEFF1 Products(1)

mRNA	Protein	Name
NM_003692.5	NP_003683.2	tomoregulin-1 precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12743596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEFF1 Protein Structure

Kazal_2

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

tomoregulin-1

cancer/testis antigen family 120, member 1

Recombinant TMEFF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76684	TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc)	Q8IYR6 (S40-V330)	≥95%

Related Diseases

Diseases

Alias

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 2

FTDALS2	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-2
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 2

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14641	TMEFF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEFF1	RGD	RGD:62005
Mus musculus	TMEFF1	MGD	MGI:1926810
Others	TMEFF1	NCBI

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