PLA2G4C - phospholipase A2 group IVC Gene

Homo sapiens

Also known as CPLA2-gamma

Gene ID: 8605 | Gene type: protein coding

About PLA2G4C

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,047,846-48,110,817 (from NCBI)

This gene has 24 transcripts (splice variants), 253 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.1), heart (RPKM 5.7) and 23 other tissues.

Summary

This gene encodes a protein which is a member of the Phospholipase A2 Enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound Enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

PLA2G4C Products(3)

mRNA	Protein	Name
NM_001159322.2	NP_001152794.1	cytosolic phospholipase A2 gamma isoform 2 precursor
NM_001159323.2	NP_001152795.1	cytosolic phospholipase A2 gamma isoform 3
NM_003706.3	NP_003697.2	cytosolic phospholipase A2 gamma isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables O-acyltransferase activity	IDA IDA: Inferred from direct assay	15944408	GOA
enables calcium-independent phospholipase A2 activity	IDA IDA: Inferred from direct assay	10085124	GOA
enables lysophospholipase activity	IDA IDA: Inferred from direct assay	15944408	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycerophospholipid catabolic process	IDA IDA: Inferred from direct assay	10085124	GOA
involved in lipid droplet formation	IMP IMP: Inferred from mutant phenotype	28336330	GOA
involved in phosphatidylcholine acyl-chain remodeling	IDA IDA: Inferred from direct assay	19501189	GOA
involved in phosphatidylethanolamine acyl-chain remodeling	IDA IDA: Inferred from direct assay	19501189	GOA
involved in platelet activating factor biosynthetic process	IDA IDA: Inferred from direct assay	19501189	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15944408	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	28336330	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	15944408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G4C Protein Structure

PLA2_B

0
100
200
300
400
500
541 a.a.

Protein Preferred Names

Protein Names

cytosolic phospholipase A2 gamma

cytosolic lysophospholipase

Related Diseases

Diseases

Alias

Pulmonary Systemic Sclerosis

Lung Disease With Systemic Sclerosis

Lung Involvement In Systemic Sclerosis

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10628	PLA2G4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLA2G4C	MGD	MGI:1196403
Rattus norvegicus	PLA2G4C	RGD	RGD:1594658

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