2. Gene
  3. B4GALT2 - beta-1,4-galactosyltransferase 2 Gene

B4GALT2 - beta-1,4-galactosyltransferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as B4Gal-T2; B4Gal-T3; beta4Gal-T2

Gene ID: 8704 | Gene type: protein coding

About B4GALT2

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,979,210-43,991,171 (from NCBI)

This gene has 8 transcripts (splice variants), 226 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 14.6), fat (RPKM 11.8) and 25 other tissues.

Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The Enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

B4GALT2 Products(3)

mRNA Protein Name
NM_001005417.2 NP_001005417.1 beta-1,4-galactosyltransferase 2 isoform b
NM_003780.5 NP_003771.1 beta-1,4-galactosyltransferase 2 isoform b
NM_030587.3 NP_085076.2 beta-1,4-galactosyltransferase 2 isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

B4GALT2 Protein Structure

Glyco_transf_7N

Glyco_transf_7N: N-terminal region of glycosyl transferase group 7 (97 - 231)

Glyco_transf_7C

Glyco_transf_7C: N-terminal domain of galactosyltransferase (235 - 311)

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  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

beta-1,4-galactosyltransferase 2

N-acetyllactosamine synthase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01320 B4GALT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus B4GALT2 RGD RGD:1305358
Mus musculus B4GALT2 MGD MGI:1858493
Macaca mulatta B4GALT2 VGNC VGNC:70209
Felis catus B4GALT2 VGNC VGNC:68986
Canis familiaris B4GALT2 VGNC VGNC:38350
Bos taurus B4GALT2 VGNC VGNC:26389