CBR1 - carbonyl reductase 1 Gene

Homo sapiens

Also known as CBR; hCBR1; PG-9-KR; SDR21C1

Gene ID: 873 | Gene type: protein coding

About CBR1

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:36,070,024-36,073,164 (from NCBI)

This gene has 5 transcripts (splice variants), 362 orthologues and 13 paralogues. Broad expression in duodenum (RPKM 163.2), small intestine (RPKM 98.7) and 19 other tissues.

Summary

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as Quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

CBR1 Products(2)

mRNA	Protein	Name
NM_001286789.2	NP_001273718.1	carbonyl reductase [NADPH] 1 isoform 2
NM_001757.4	NP_001748.1	carbonyl reductase [NADPH] 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables carbonyl reductase (NADPH) activity	IDA IDA: Inferred from direct assay	1921984	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	19442656	GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA IDA: Inferred from direct assay	28878267	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26496610	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in glucocorticoid metabolic process	IDA IDA: Inferred from direct assay	28878267	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in vitamin K metabolic process	IDA IDA: Inferred from direct assay	18449627	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	18449627	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBR1 Protein Structure

adh_short

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

carbonyl reductase [NADPH] 1

15-hydroxyprostaglandin dehydrogenase

Recombinant CBR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72272	CBR1 Protein, Human (P.pastoris, His)	P16152 (S2-W277)	≥95%

Related Diseases

Diseases

Alias

Constipation

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Depersonalization Disorder

Neurotic Derealization	Depersonalization
Depersonalization/Derealization Disorder	Depersonalisation-Derealization Syndrome
Depersonalisation Disorder	Depersonalisation Neurosis
Depersonalisation Syndrome	Feeling Of Unreality
Feels Own Self Is Unreal	Neurotic State With Depersonalisation
Neurotic State With Depersonalization Episode

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0148	Rutin		98.06%	Unkown

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13930	Miquelianin		99.70%	Unkown
HY-N2609	7,4'-Dihydroxyflavone	Inhibitor	99.68%	Unkown
HY-156694	Hydroxy-PP-Me	Modulator	99.92%	Unkown
HY-155587	Hydroxy-PP		99.66%	Unkown
HY-121710	MonoHER		/	Unkown
HY-157444	5,3',4',3'',4'',5''-6-O-Ethyl-EGCG	Inhibitor	/	Unkown
HY-157445	CBR1-IN-3		/	Unkown
HY-157447	CBR1-IN-4		/	Unkown
HY-157448	CBR1-IN-6	Inducer	/	Unkown
HY-157449	CBR1-IN-5		/	Unkown
HY-157450	YF-Mo1		/	Unkown
HY-157451	CBR1-IN-7		/	Unkown
HY-157452	(8S)-Methyl zearalenone	Inhibitor	/	Unkown
HY-RS02004	CBR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CBR1	RGD	RGD:7631561
Macaca mulatta	CBR1	VGNC	VGNC:80854
Mus musculus	CBR1	MGD	MGI:88284
Others	CBR1	NCBI

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