2. Gene
  3. SNX18 - sorting nexin 18 Gene

SNX18 - sorting nexin 18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SNAG1; SH3PX2; SH3PXD3B

Gene ID: 112574 | Gene type: protein coding

About SNX18

This gene has 3 transcripts (splice variants), 271 orthologues and 15 paralogues. Ubiquitous expression in bone marrow (RPKM 13.6), ovary (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SNX18 Products(3)

mRNA Protein Name
NM_001102575.2 NP_001096045.1 sorting nexin-18 isoform a
NM_001145427.2 NP_001138899.1 sorting nexin-18 isoform c
NM_052870.4 NP_443102.2 sorting nexin-18 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
23878278 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20427313 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cleavage furrow formation IMP
IMP: Inferred from mutant phenotype
22718350 GOA
involved in endocytosis IDA
IDA: Inferred from direct assay
20427313 GOA
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
22718350 GOA
involved in endosomal transport IMP
IMP: Inferred from mutant phenotype
22718350 GOA
involved in mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
22718350 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
20427313 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
29437695 GOA
involved in protein transport IMP
IMP: Inferred from mutant phenotype
29437695 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with clathrin-coated vesicle IDA
IDA: Inferred from direct assay
20427313 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
20427313 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
22718350 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
15326289 GOA
is active in recycling endosome membrane IMP
IMP: Inferred from mutant phenotype
29437695 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX18 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (7 - 57)

PX

PX: PX domain (278 - 380)

BAR_3_WASP_bdg

BAR_3_WASP_bdg: WASP-binding domain of Sorting nexin protein (386 - 541)

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  • 628 a.a.
Protein Preferred Names Protein Names

sorting nexin-18

SH3 and PX domain-containing protein 3B

SNX18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SNX18 Q96RF0 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
SNX18 Q96RF0 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
SNX18 Q96RF0 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 CPSF7 Homo sapiens Q8N684-3
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 CPSF7 Homo sapiens Q8N684-3
Y2H Array
32296183
Intra
SNX18 Q96RF0 MSS51 Homo sapiens Q4VC12
Y2H Array
32296183
Intra
SNX18 Q96RF0 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
SNX18 Q96RF0 ZBTB42 Homo sapiens B2RXF5
Y2H Array
32296183
Intra
SNX18 Q96RF0 ZBTB42 Homo sapiens B2RXF5
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 RAB11FIP5 Homo sapiens Q9BXF6
Pull Down
24591568
Intra
SNX18 Q96RF0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
SNX18 Q96RF0 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
Intra
SNX18 Q96RF0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SNX18 Q96RF0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
SNX18 Q96RF0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 DPPA4 Homo sapiens Q7L190
Validated Y2H
32296183
Intra
SNX18 Q96RF0 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra
SNX18 Q96RF0 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
SNX18 Q96RF0 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra
SNX18 Q96RF0 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
SNX18 Q96RF0 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
SNX18 Q96RF0 HSPB2 Homo sapiens Q16082
Y2H Prey Pooling
32296183
Intra
SNX18 Q96RF0 HSPB2 Homo sapiens Q16082
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13531 SNX18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SNX18 MGD MGI:2137642
Canis familiaris SNX18 VGNC VGNC:46627
Macaca mulatta SNX18 VGNC VGNC:77738
Felis catus SNX18 VGNC VGNC:65548
Rattus norvegicus SNX18 RGD RGD:1310367
Bos taurus SNX18 VGNC VGNC:35098