2. Gene
  3. CD164 - CD164 molecule Gene

CD164 - CD164 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DFNA66; MGC-24; MUC-24; MGC-24v; endolyn

Gene ID: 8763 | Gene type: protein coding

About CD164

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,366,514-109,382,467 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 246.6), fat (RPKM 191.2) and 25 other tissues.

Summary

This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C Chemokine Receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood Cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]

CD164 Products(6)

mRNA Protein Name
NM_001142401.3 NP_001135873.1 sialomucin core protein 24 isoform 2 precursor
NM_001142402.3 NP_001135874.1 sialomucin core protein 24 isoform 3 precursor
NM_001142403.3 NP_001135875.1 sialomucin core protein 24 isoform 4 precursor
NM_001142404.3 NP_001135876.1 sialomucin core protein 24 isoform 5 precursor
NM_001346500.2 NP_001333429.1 sialomucin core protein 24 isoform 6
NM_006016.6 NP_006007.2 sialomucin core protein 24 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17077324 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
10491205 GOA
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
10491205 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endosome IDA
IDA: Inferred from direct assay
11027692 GOA
located in lysosome IDA
IDA: Inferred from direct assay
11027692 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10491205 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD164 Protein Structure

MGC-24

MGC-24: Multi-glycosylated core protein 24 (MGC-24), sialomucin (5 - 189)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

sialomucin core protein 24

CD164 antigen, sialomucin

CD164 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CD164 Q04900 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
CD164 Q04900 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
CD164 Q04900 CXCR4 Homo sapiens P61073
Anti Bait CoIP
24094005
Intra
CD164 Q04900 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
CD164 Q04900 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
CD164 Q04900 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD164 Proteins

Cat. No. Product Name Accession Purity
HY-P75617 CD164 Protein, Human (HEK293, His) Q04900 (D24-D162) ≥95%

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 66

DFNA66

Autosomal Dominant Nonsyndromic Deafness 66

Autosomal Dominant Deafness 66

Deafness, Autosomal Dominant, 66
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Isolated Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02194 CD164 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02195 CD164L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CD164 VGNC VGNC:70753
Felis catus CD164 VGNC VGNC:102397
Rattus norvegicus CD164 RGD RGD:70942
Mus musculus CD164 MGD MGI:1859568
Bos taurus CD164 VGNC VGNC:27004
Canis familiaris CD164 VGNC VGNC:38932
Macaca fascicularis CD164 NCBI NCBI:102136974
Others CD164 NCBI