2. Recombinant Proteins
  3. Receptor Proteins
  4. G-Protein-Coupled Receptors (GPCRs)
  5. Chemokine Receptor

Chemokine Receptor

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72674
    CXCR4 Protein, Human (HEK293, Fc)

    C-X-C chemokine receptor type 4; CXC-R4; LESTR; LAP-3; NPYRL; CD184; SDF-1 receptor

    		Human HEK293
    The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (HEK293, Fc) is the recombinant human-derived CXCR4 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CXCR4 Protein, Human (HEK293, Fc) is 46 a.a., with molecular weight of 35-45 kDa.
  • HY-P77589
    CCR2b Protein-VLP, Human (HEK293)

    C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

    		Human HEK293
    CCR2b Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.
  • HY-P700380
    ACKR1 Protein, Human (Cell-Free, His)

    ACKR1; atypical chemokine receptor 1 (Duffy blood group); DARC; Duffy blood group, chemokine receptor; Duffy blood group , FY; Duffy antigen/chemokine receptor; CCBP1; CD234; Dfy; GPD; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; FY; GpFy; WBCQ1;

    		Human E. coli Cell-free
    ACKR1 is an atypical chemokine receptor that regulates chemokine levels and localization through high-affinity binding, induction of sequestration, degradation, or transcytosis. ACKR1, also known as a chemokine interceptor or decoy receptor, binds to chemokines such as CXCL11 and CXCL12/SDF1. ACKR1 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.
  • HY-P72159
    CXCR4 Protein, Human (N-His-SUMO, C-Myc)

    C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; SDF 1 receptor; SDF-1 receptor; WHIM; WHIMS

    		Human E. coli
    The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (N-His-SUMO, C-Myc) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of CXCR4 Protein, Human (N-His-SUMO, C-Myc) is 50 a.a., with molecular weight of ~28 kDa.
  • HY-P700536
    CXCR2 Protein, Human (His-SUMO)

    C-X-C motif chemokine receptor 2; IL8RB, interleukin 8 receptor, beta; C-X-C chemokine receptor type 2; CD182; CMKAR2;

    		Human E. coli
    CXCR2, the receptor for interleukin-8 (IL-8), orchestrates neutrophil activation through a G-protein-mediated phosphatidylinositol-calcium second messenger system upon IL-8 binding. Exhibiting high-affinity binding to IL-8, CXCR2 also interacts with other ligands like CXCL3, GRO/MGSA, and NAP-2. The involvement of GNAI2 underscores the intricate signaling mechanisms regulating neutrophil function through CXCR2. CXCR2 Protein, Human (His-SUMO) is the recombinant human-derived CXCR2 protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of CXCR2 Protein, Human (His-SUMO) is 40 a.a., with molecular weight of 20.6 kDa.
  • HY-P700537
    ACKR3 Protein, Human (His-SUMO)

    RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159;

    		Human E. coli
    ACKR3 is an atypical chemokine receptor that precisely controls chemokine levels and localization through high-affinity binding, operating independently of ligand-driven signaling. It acts as an interceptor, internalization receptor, and chemokine scavenger for CXCL11 and CXCL12/SDF1, inducing β-arrestin recruitment, ligand internalization, and MAPK pathway activation. ACKR3 Protein, Human (His-SUMO) is the recombinant human-derived ACKR3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of ACKR3 Protein, Human (His-SUMO) is 40 a.a., with molecular weight of 20.5 kDa.
  • HY-P700540
    CCR5 Protein, Mouse (P. pastoris, His)

    CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); chemokine (C C motif) receptor 5, CMKBR5; C-C chemokine receptor type 5; CC CKR 5; CD195; CKR 5; CKR5; IDDM22; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; CCR-5; CKR-5; CCCKR5; CMKBR5; CC-CKR-5; FLJ78003;

    		Mouse P. pastoris
    CCR5 Protein, a receptor for inflammatory CC-chemokines, including CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, plays a crucial role in signal transduction by increasing intracellular calcium ion levels. It contributes to granulocytic lineage control and T-lymphocyte migration to infection sites, serving as a chemotactic receptor. Interactions with PRAF2, GRK2, ARRB1, ARRB2, and CNIH4 highlight CCR5's regulatory network complexity. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation, and sialic acid modifications. Glycosylation on Ser-6 is essential for optimal CCL4 binding. The stimulating effect on T-lymphocyte chemotaxis, observed in interaction with S100A4, emphasizes CCR5's multifaceted roles in immune responses and cellular signaling pathways. CCR5 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived CCR5 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of CCR5 Protein, Mouse (P. pastoris, His) is 92 a.a., with molecular weight of 12.6 kDa.
  • HY-P700541
    CCR2 Protein, Mouse (N-His, C-Myc)

    CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2

    		Mouse E. coli
    CCR2 protein is an important chemokine receptor that coordinates chemotaxis and migration by binding to CCL2, CCL7, and CCL12 and activating the PI3K cascade. In addition to chemokine signaling, CCR2 regulates T cell inflammatory cytokines, promotes Th17 cell generation, and promotes mature thymocyte output. CCR2 Protein, Mouse (N-His, C-Myc) is the recombinant mouse-derived CCR2 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of CCR2 Protein, Mouse (N-His, C-Myc) is 55 a.a., with molecular weight of 13.6 kDa.
  • HY-P700544
    CCR9 Protein, Human (GST)

    chemokine (C-C motif) receptor 9; GPR28; C-C chemokine receptor type 9; CDw199; GPR 9 6; G protein-coupled receptor 28; GPR-9-6; CC-CKR-9;

    		Human E. coli
    CCR9 Protein, a receptor for SCYA25/TECK, activates signaling, elevating intracellular calcium ions. In microbial infection, it acts as an alternative HIV-1 coreceptor with CD4, influencing the infection process. CCR9 Protein, Human (GST) is the recombinant human-derived CCR9 protein, expressed by E. coli , with N-GST labeled tag.
  • HY-P700546
    CXCR4 Protein, Human (Cell-Free, His)

    C-X-C chemokine receptor type 4; CXC-R4; LESTR; LAP-3; NPYRL; CD184; SDF-1 receptor

    		Human E. coli Cell-free
    The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR4 protein, expressed by E. coli Cell-free , with N-6*His labeled tag. The total length of CXCR4 Protein, Human (Cell-Free, His) is 356 a.a., the molecular weight are 44 KDa (monomer), 100 KDa (dimer), whiel dimers are generally formed.
  • HY-P702257
    CXCR2 Protein, Mouse (Cell-Free, His)

    C-X-C chemokine receptor type 2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; CD182

    		Mouse E. coli Cell-free
    CXCR2 protein acts as a receptor for interleukin-8 and induces neutrophil activation through the G protein-mediated phosphatidylinositol-calcium second messenger system. In addition to IL-8, CXCR2 also exhibits high-affinity binding to ligands such as CXCL3, GRO/MGSA, and NAP-2. CXCR2 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CXCR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CXCR2 Protein, Mouse (Cell-Free, His) is 359 a.a., with molecular weight of 43.2 kDa.
  • HY-P702830
    CCR5 Protein, Human (HEK293, Flag, His, Strep)

    C-C chemokine receptor type 5; CHEMR13; HIV-1 fusion coreceptor

    		Human HEK293
    CCR5 Protein, a receptor for inflammatory CC-chemokines like CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, transduces signals, elevating intracellular calcium levels. It regulates granulocytic lineage and facilitates T-lymphocyte migration to infection sites. In microbial infection, CCR5 acts as a coreceptor, along with CD4, for HIV-1, emphasizing its role in the cellular response to infections. CCR5 Protein, Human (HEK293, Flag, His, Strep) is the recombinant human-derived CCR5 protein, expressed by HEK293 Cell-free , with N-Flag, C-His, C-Strep labeled tag.
  • HY-P700399
    CCR4 Protein-VLP, Human (HEK293, His)

    CCR4; CMKBR4; C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD antigen CD194

    		Human HEK293
    CCR4 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
  • HY-P700400
    CCR8 Protein-VLP, Human (HEK293, His)

    CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973

    		Human HEK293
    CCR8 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
  • HY-P77590
    CCR2b Protein-VLP, Human (Biotinylated, HEK293)

    C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

    		Human HEK293
    CCR2b Protein-VLP, Human (Biotinylated, HEK293) is available in solution form, no concentration information, recommended only for SPR analysis. HY-P77589 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.
  • HY-P700965
    CCR8 Protein, Cynomolgus (HEK293, mFc)

    CCR-8; CMKBRL2; CKR-L1; GPR-CY6; GPRCY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CKR-L1; CY6; TER-1; CDw198

    		Cynomolgus HEK293
    CCR8 is part of the G-protein coupled receptor 1 family. CCR8 Protein, Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived CCR8 protein, expressed by HEK293 , with C-mFc labeled tag.
  • HY-P702258
    CXCR4-VLP Protein, Human (HEK293, His)

    CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184

    		Human HEK293
    CXCR4-VLP Protein, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
  • HY-P72160
    CXCR4 Protein, Human (GST)

    C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR; Stromal cell derived factor 1 receptor; Stromal cell-derived factor 1 receptor; WHIM; WHIMS

    		Human E. coli
    The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (GST) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-GST labeled tag. The total length of CXCR4 Protein, Human (GST) is 50 a.a., with molecular weight of ~32.6 kDa.
  • HY-P700378
    ACKR2 Protein, Human (Cell-Free, His)

    ACKR2; atypical chemokine receptor 2; CCBP2; chemokine binding protein 2; CMKBR9; chemokine-binding protein 2; CCR9; CCR10; D6; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61; hD6; MGC126678; MGC138250;

    		Human E. coli Cell-free
    ACKR2 Protein, an atypical chemokine receptor, controls chemokine levels and localization with high-affinity binding. Operating independently, ACKR2, also known as an interceptor or decoy receptor, interacts with diverse chemokines, triggering a beta-arrestin 1-dependent signaling pathway. This pathway facilitates ACKR2 relocation, enhancing efficiency in chemokine uptake and degradation. Scavenging chemokines in various tissues, ACKR2 plays a pivotal role in resolving inflammation, regulating adaptive immune responses, and influencing leukocyte interactions with lymphatic endothelial cells. ACKR2 contributes significantly to immune silencing of macrophages during inflammation resolution. ACKR2 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of ACKR2 Protein, Human (Cell-Free, His) is 384 a.a., with molecular weight of 46.9 kDa.
  • HY-P700539
    CXCR3 Protein, Human (Cell-Free, His)

    G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine C-X-C receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R;

    		Human E. coli Cell-free
    The CXCR3 protein acts as a receptor for CXC chemokines (CXCL9, CXCL10, and CXCL11), affecting human mesangial cells (HMC) through G protein signaling. It binds CCL21 and may promote cell chemotaxis. CXCR3 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR3 protein, expressed by E. coli Cell-free , with C-10*His labeled tag.
Cat. No. Product Name Effect Purity