CREG1 - cellular repressor of E1A stimulated genes 1 Gene

Homo sapiens

Also known as CREG

Gene ID: 8804 | Gene type: protein coding

About CREG1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:167,541,013-167,553,762 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 83.3), thyroid (RPKM 78.7) and 25 other tissues.

Summary

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

CREG1 Products(1)

mRNA	Protein	Name
NM_003851.3	NP_003842.1	protein CREG1 precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	25645918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREG1 Protein Structure

Pyrid_oxidase_2

0
100
200
220 a.a.

Protein Preferred Names

Protein Names

protein CREG1

Recombinant CREG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7849	CREG1/CREG Protein, Human (HEK293, His)	O75629 (R32-Q220)	≥95%

Related Diseases

Diseases

Alias

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Ornithosis

Psittacosis	Chlamydial Pneumonia
Chlamydia Psittaci Infection	Chlamydia Psittaci

Spondyloarthropathy

Spondylarthropathies	Spondarthropathy
Spondylarthrosis	Spondyloarthropathy, Susceptibility To
Spondylarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03161	CREG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CREG1	VGNC	VGNC:61174
Canis familiaris	CREG1	VGNC	VGNC:39605
Bos taurus	CREG1	VGNC	VGNC:27702
Macaca mulatta	CREG1	VGNC	VGNC:106346
Rattus norvegicus	CREG1	RGD	RGD:1306804
Mus musculus	CREG1	MGD	MGI:1344382
Others	CREG1	NCBI

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