AKAP4 - A-kinase anchoring protein 4 Gene

Homo sapiens

Also known as HI; p82; CT99; FSC1; PRKA4; AKAP-4; AKAP82; AKAP 82; hAKAP82

Gene ID: 8852 | Gene type: protein coding

About AKAP4

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:50,190,777-50,201,007 (from NCBI)

This gene has 6 transcripts (splice variants), 127 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 101.7).

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

AKAP4 Products(2)

mRNA	Protein	Name
NM_003886.3	NP_003877.2	A-kinase anchor protein 4 isoform 1
NM_139289.2	NP_647450.1	A-kinase anchor protein 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27913189	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	9822690	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in motile cilium	IDA IDA: Inferred from direct assay	9822690	GOA
located in sperm end piece	IDA IDA: Inferred from direct assay	30745215	GOA
is active in sperm fibrous sheath	IDA IDA: Inferred from direct assay	9822690	GOA
is active in sperm flagellum	IDA IDA: Inferred from direct assay	34415320	GOA
located in sperm head-tail coupling apparatus	IDA IDA: Inferred from direct assay	30745215	GOA
located in sperm midpiece	IDA IDA: Inferred from direct assay	30745215	GOA
located in sperm principal piece	IDA IDA: Inferred from direct assay	30137358	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP4 Protein Structure

RII_binding_1

AKAP_110

0
200
400
600
800
854 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 4

A kinase (PRKA) anchor protein 4

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 70

RP70	Retinitis Pigmentosa, Type 70

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00519	AKAP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKAP4	RGD	RGD:620828
Mus musculus	AKAP4	MGD	MGI:102794
Canis familiaris	AKAP4	VGNC	VGNC:37757
Bos taurus	AKAP4	VGNC	VGNC:25785
Felis catus	AKAP4	VGNC	VGNC:59714
Macaca mulatta	AKAP4	VGNC	VGNC:69770

Name
Email *

	Sorry, but the email address you supplied was invalid.