PROZ - protein Z, vitamin K dependent plasma glycoprotein Gene

Homo sapiens

Also known as PZ

Gene ID: 8858 | Gene type: protein coding

About PROZ

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,158,648-113,172,386 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in liver (RPKM 5.4), kidney (RPKM 4.0) and 1 other tissue.

Summary

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent Protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

PROZ Products(2)

mRNA	Protein	Name
NM_001256134.2	NP_001243063.1	vitamin K-dependent protein Z isoform 1 precursor
NM_003891.3	NP_003882.1	vitamin K-dependent protein Z isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20427285	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROZ Protein Structure

Gla

EGF

FXa_inhibition

Trypsin

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

vitamin K-dependent protein Z

Related Diseases

Diseases

Alias

Protein Z Deficiency

Cerebral Sinovenous Thrombosis

Csvt

Coumarin Resistance

Warfarin Resistance	Warfarin Sensitivity
Coumadin Sensitivity	Warfarin Response
Poor Metabolism Of Coumarin	Coumarin, Poor Metabolism Of
CMRES

Brain Small Vessel Disease 2

Porencephaly 2	BSVD2
Gould Syndrome 2	Porencephaly 2, Formerly
Poren2, Formerly	Poren2

Palmoplantar Keratoderma, Bothnian Type

PPKB	Diffuse Palmoplantar Keratoderma, Bothnian Type
Bothnian Type Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Bothnian Type
Palmoplantar Keratoderma, Nonepidermolytic

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11205	PROZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PROZ	RGD	RGD:1308666
Macaca mulatta	PROZ	VGNC	VGNC:76428
Bos taurus	PROZ	VGNC	VGNC:33371
Mus musculus	PROZ	MGD	MGI:1860488

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