2. Gene
  3. DDX18 - DEAD-box helicase 18 Gene

DDX18 - DEAD-box helicase 18 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Has1; MrDb

Gene ID: 8886 | Gene type: protein coding

About DDX18

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:117,814,691-117,832,377 (from NCBI)

This gene has 6 transcripts (splice variants), 221 orthologues and 38 paralogues. Ubiquitous expression in lymph node (RPKM 23.5), thyroid (RPKM 21.0) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

DDX18 Products(1)

mRNA Protein Name
NM_006773.4 NP_006764.3 ATP-dependent RNA helicase DDX18
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16963496 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromosome IDA
IDA: Inferred from direct assay
20813266 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
16963496 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX18 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (203 - 374)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (444 - 518)

DUF4217

DUF4217: Domain of unknown function (DUF4217) (560 - 621)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DDX18

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18

Related Diseases

Diseases Alias
Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03633 DDX18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DDX18 VGNC VGNC:61399
Mus musculus DDX18 MGD MGI:1914192
Canis familiaris DDX18 VGNC VGNC:39847
Rattus norvegicus DDX18 RGD RGD:1549712
Macaca mulatta DDX18 VGNC VGNC:84227