BSN - bassoon presynaptic cytomatrix protein Gene

Homo sapiens

Also known as ZNF231

Gene ID: 8927 | Gene type: protein coding

About BSN

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,554,477-49,673,130 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues and 1 paralogue. Biased expression in brain (RPKM 13.0), testis (RPKM 2.3) and 1 other tissue.

Summary

Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of Cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic Cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]

BSN Products(1)

mRNA	Protein	Name
NM_003458.4	NP_003449.2	protein bassoon

BSN Protein Structure

zf-piccolo

0
700
1400
2100
2800
3500
3926 a.a.

Protein Preferred Names

Protein Names

protein bassoon

neuronal double zinc finger protein

Related Diseases

Diseases

Alias

Cork-Handlers' Disease

Suberosis	Cork-Handlers' Disease Or Lung
Cork-Handlers' Lung	Corkhandler Disease
Corkworker Lung	Corkhandler Hypersensitivity Pneumonitis
Cork-Handler Disease	Cork-Handler Lung

Cone-Rod Dystrophy 7

CORD7	Dystrophy, Cone-Rod, Type 7
Retinitis Pigmentosa 7

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114591	Spiromesifen	Inhibitor	97.20%	Unkown
HY-114591S	Spiromesifen-d9		/	Unkown
HY-RS01644	BSN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BSN	VGNC	VGNC:54578
Mus musculus	BSN	MGD	MGI:1277955
Rattus norvegicus	BSN	RGD	RGD:2223
Felis catus	BSN	VGNC	VGNC:60188
Bos taurus	BSN	VGNC	VGNC:59321
Macaca mulatta	BSN	VGNC	VGNC:70284

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