UMODL1 - uromodulin like 1 Gene

Homo sapiens

Gene ID: 89766 | Gene type: protein coding

About UMODL1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,062,877-42,142,996 (from NCBI)

This gene has 14 transcripts (splice variants), 178 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

Predicted to be an extracellular matrix structural constituent. Predicted to be involved in neutrophil migration. Predicted to act upstream of or within several processes, including adipose tissue development; cellular response to gonadotropin-releasing hormone; and regulation of ovarian follicle development. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be integral component of membrane. Predicted to be active in apical plasma membrane; cell surface; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

UMODL1 Products(4)

mRNA	Protein	Name
NM_001004416.3	NP_001004416.3	uromodulin-like 1 isoform 1 precursor
NM_001199527.3	NP_001186456.2	uromodulin-like 1 isoform 3
NM_001199528.4	NP_001186457.3	uromodulin-like 1 isoform 4
NM_173568.4	NP_775839.4	uromodulin-like 1 isoform 2 precursor

UMODL1 Protein Structure

EMI

WAP

EGF_CA

SEA

EGF_CA

SEA

EGF_CA

Zona_pellucida

0
300
600
900
1200
1318 a.a.

Protein Preferred Names

Protein Names

uromodulin-like 1

olfactorin

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 8

Neurosensory Nonsyndromic Recessive Deafness 8	DFNB8
Dfnb10	Deafness, Autosomal Recessive 10
Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8	Nsrd8
Autosomal Recessive Nonsyndromic Deafness 8	Deafness, Autosomal Recessive 8/10
Autosomal Recessive Deafness 10	Autosomal Recessive Deafness 8
Childhood-Onset Neurosensory Autosomal Recessive Deafness 8	Nrsd8
Deafness, Autosomal Recessive, 8	Childhood-Onset Neurosensory Deafness Autosomal Recessive 8
Deafness Autosomal Recessive 10	Deafness Autosomal Recessive 8/10
Deafness Neurosensory Autosomal Recessive 8	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8	Deafness, Autosomal Recessive, Type 8/10

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15460	UMODL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UMODL1	VGNC	VGNC:66819
Bos taurus	UMODL1	VGNC	VGNC:52839
Rattus norvegicus	UMODL1	RGD	RGD:1566039
Mus musculus	UMODL1	MGD	MGI:1929785
Macaca mulatta	UMODL1	VGNC	VGNC:78717
Canis familiaris	UMODL1	VGNC	VGNC:53049

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