ARHGAP11B - Rho GTPase activating protein 11B Gene

Homo sapiens

Also known as B'-T; FAM7B1; GAP (1-8)

Gene ID: 89839 | Gene type: protein coding

About ARHGAP11B

Cytogenetic location: 15q13.2 Genomic coordinates (GRCh38): 15:30,626,128-30,649,229 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 244 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 7.6), lymph node (RPKM 4.9) and 16 other tissues.

Summary

Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP11B Products(1)

mRNA	Protein	Name
NM_001039841.3	NP_001034930.1	inactive Rho GTPase-activating protein 11B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables GTPase activator activity	IDA IDA: Inferred from direct assay	25721503	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31883789	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebral cortex development	IDA IDA: Inferred from direct assay	25721503	GOA
acts upstream of positive effect glutamine catabolic process	IDA IDA: Inferred from direct assay	31883789	GOA
involved in negative regulation of mitochondrial membrane permeability	IDA IDA: Inferred from direct assay	31883789	GOA
NOT involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	27957544	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	31883789	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP11B Protein Structure

RhoGAP

0
100
200
267 a.a.

Protein Preferred Names

Protein Names

inactive Rho GTPase-activating protein 11B

family with sequence similarity 7, member B1

Related Diseases

Diseases

Alias

Chromosome 15q13.3 Deletion Syndrome

Chromosome 15q13.3 Microdeletion Syndrome	15q13.3 Microdeletion Syndrome
15q13.3 Microdeletion	Microdeletion 15q13.3 Syndrome
Del(15)(Q13.3)	Monosomy 15q13.3

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis	KMIN
Kin	Systemic Karyomegaly
Karyomegalic Tubulointerstitial Nephritis	Ktn

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00914	ARHGAP11B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARHGAP11B	MGD	MGI:2444300

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