ACVR1 - activin A receptor type 1 Gene

Homo sapiens

Also known as FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2

Gene ID: 90 | Gene type: protein coding

About ACVR1

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:157,736,446-157,876,330 (from NCBI)

This gene has 26 transcripts (splice variants), 174 orthologues, 11 paralogues and is associated with 77 phenotypes. Ubiquitous expression in thyroid (RPKM 15.1), gall bladder (RPKM 9.4) and 23 other tissues.

Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes Activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

ACVR1 Products(7)

mRNA	Protein	Name
NM_001347667.2	NP_001334596.1	activin receptor type-1 precursor
NM_001347664.1	NP_001334593.1	activin receptor type-1 precursor
NM_001111067.4	NP_001104537.1	activin receptor type-1 precursor
NM_001105.5	NP_001096.1	activin receptor type-1 precursor
NM_001347663.1	NP_001334592.1	activin receptor type-1 precursor
NM_001347666.1	NP_001334595.1	activin receptor type-1 precursor
NM_001347665.1	NP_001334594.1	activin receptor type-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables BMP receptor activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables SMAD binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables activin binding	IDA IDA: Inferred from direct assay	8242742	GOA
contributes to activin receptor activity, type I	IDA IDA: Inferred from direct assay	8242742	GOA
enables cadherin binding	IPI IPI: Inferred from physical interaction	26598555	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8242742	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18436533	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	19736306	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	26598555	GOA
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	8242742	GOA
enables transmembrane receptor protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19506109	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	12065756	GOA
involved in activin receptor signaling pathway	IDA IDA: Inferred from direct assay	19506109	GOA
involved in activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in atrial septum primum morphogenesis	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in cardiac muscle cell fate commitment	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in cellular response to BMP stimulus	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in endocardial cushion cell fate commitment	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in negative regulation of activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in negative regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8242742	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	19506109	GOA
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	18436533	GOA
involved in positive regulation of cell migration	IGI IGI: Inferred from genetic interaction	19736306	GOA
involved in positive regulation of determination of dorsal identity	IDA IDA: Inferred from direct assay	19506109	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	18436533	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	26598555	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19506109	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in regulation of ossification	IMP IMP: Inferred from mutant phenotype	16642017	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	8242742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of activin receptor complex	IDA IDA: Inferred from direct assay	8242742	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8242742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACVR1 Protein Structure

Activin_recp

TGF_beta_GS

Pkinase

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

activin receptor type-1

TGF-B superfamily receptor type I	activin A receptor, type I
activin A receptor, type II-like kinase 2	activin receptor type I
activin receptor-like kinase 2	hydroxyalkyl-protein kinase
serine/threonine-protein kinase receptor R1

Recombinant ACVR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7482	Activin RIA Protein, Human (HEK293, His)	Q04771 (M21-V124)	≥95%
HY-P72812	Activin RIA Protein, Human (HEK293, His-Fc)	Q04771 (M21-V124)	≥95%

Related Diseases

Diseases

Alias

Epicanthus

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Proximal Symphalangism

Cushing'S Symphalangism	Symphalangism, Proximal
Hereditary Absence Of Proximal Interphalangeal Joints	Strasburger-Hawkins-Eldridge Syndrome
Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome	Symphalangism, Proximal, 1a
Symphalangism, Proximal, 1b	Vessel'S Syndrome
Symphalangism, Cushing Type

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease	Hht
Osler-Weber-Rendu Disease	Telangiectasia, Hereditary Hemorrhagic
Osler Hemorrhagic Telangiectasia Syndrome	Orw Disease
Osler Weber Rendu Syndrome	Osler-Rendu-Weber Disease
Osler-Weber-Rendu Syndrome	Rendu-Osler Disease
Telangiectasia Hereditary Hemorrhagic	Telangiectasia Hemorrhagic, Hereditary
Hht - [Hereditary Haemorrhagic Telangiectasia]	Osler Haemorrhagic Telangiectasia Syndrome

Hyperostosis

Hypertrophy Of Bone	Bone Hypertrophy
Bone Thickening	Periosteum Thickening

Persistent Mullerian Duct Syndrome

Persistent Müllerian Duct Syndrome	Pmds
Persistent Oviduct Syndrome	Persistent Muellerian Duct Syndrome
Female Genital Ducts In Otherwise Normal Male	Hernia Uteri Inguinale
Persistent Mullerian Duct Syndrome, Types 1 And 2	Persistent Mullerian Derivatives

Brain Stem Cancer

Brain Stem Neoplasms	Malignant Neoplasm Of Brain Stem
Malignant Neoplasm Of Brainstem	Neoplasm Of Adult Brain Stem
Neoplasm Of Brain Stem	Primary Brain Stem Neoplasm
Primary Brain Stem Tumor	Brain Stem Neoplasm
Brain Stem--Cancer	Brain Stem Neoplasms, Primary

Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia	CMDD
Cmdj	Cmd
Autosomal Dominant Craniometaphyseal Dysplasia	Craniometaphyseal Dysplasia, Jackson Type
Craniometaphyseal Dysplasia Jackson Type	Autosomal Recessive Craniometaphyseal Dysplasia
Cmdr	Dysplasia, Craniometaphyseal, Autosomal Dominant
Craniometaphyseal Dysplasia, Autosomal Recessive Type

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva	Progressive Myositis Ossificans
FOP	Progressive Ossifying Myositis
Myositis Ossificans	Stone Man Syndrome
Man Of Stone	Myositis Ossificans Progressive
Diffuse Progressive Ossifying Polymyositis	Fibrodysplasia Ossificans Congenita
Myositis Ossificans Progressiva, Site Unspecified	Münchmeyer Disease
Fop - [Fibrodysplasia Ossificans Progressiva]	Progressive Myositis Ossificans Calcification

Diffuse Idiopathic Skeletal Hyperostosis

Hyperostosis, Diffuse Idiopathic Skeletal	Ankylosing Vertebral Hyperostosis
Dish	Disseminated Idiopathic Skeletal Hyperostosis
Forestier Disease	Forestier'S Disease
Hyperostosis Diffuse Idiopathic Skeletal

Leber Congenital Amaurosis 17

LCA17

Leber Congenital Amaurosis, Type 17

Microphthalmia, Syndromic 6

MCOPS6	Microphthalmia And Pituitary Anomalies
Microphthalmia With Brain And Digit Anomalies	Microphthalmia With Brain And Digit Developmental Anomalies
Syndromic Microphthalmia Type 6	Syndromic Microphthalmia 6
Anophthalmia Clinical With Micrognathia Malformed Ears Digital Anomalies And Abnormal External Genitalia	Bakrania-Ragge Syndrome
Orofacial Cleft 11	Anophthalmia, Clinical, With Micrognathia, Malformed Ears, Digital Anomalies, And Abnormal External Genitalia
Microphthalmia Syndromic 6	Microphthalmia, Syndromic, 6
Clinical Anophthalmia With Micrognathia, Malformed Ears, Digital Anomalies And Abnormal External Genitalia	Microphthalmia Syndromic, Type 6

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Atrioventricular Septal Defect

AVSD	Atrioventricular Canal Defect
Avcd	Endocardial Cushion Defect
Ecd	Avc Defect
Atrioventricular Septal Defect, Susceptibility To, 1	Atrioventricular Septal Defect 1
Endocardial Cushion Defects	Septal Defect, Atrioventricular
Atrioventricular Defect With Atrial Shunting Only	Incomplete Atrioventricular Septal Defect With Isolated Atrial Component
Incomplete Atrioventricular Canal Defect With Isolated Atrial Component	Primum Atrial Septal Defect
Partial Atrioventricular Canal Defect With Isolated Atrial Component	Partial Atrioventricular Septal Defect, Ostium Primum Type
Ostium Primum Atrial Septal Defect	Partial Atrioventricular Canal Defect
Partial Atrioventricular Septal Defect	Atrial Septum Primum Defect
Atrioventricular Canal Defect With Isolated Ventricular Component	Atrioventricular Canal Defect With Isolated Ventricular Communication
Atrioventricular Septal Defect With Isolated Ventricular Component	Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting
Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve	Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves
Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect	Intermediate Atrioventricular Canal Defect
Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices	Intermediate Atrioventricular Septal Defect
Transitional Atrioventricular Canal Defect	Transitional Atrioventricular Septal Defect
Complete Atrioventricular Canal With Atrial And Ventricular Components	Complete Atrioventricular Canal Defect
Complete Atrioventricular Septal Defect

Pseudohypoparathyroidism, Type Ia

Albright'S Hereditary Osteodystrophy	Albright Hereditary Osteodystrophy
Pseudohypoparathyroidism Type 1a	PHP1A
Albright Hereditary Osteodystrophy With Multiple Hormone Resistance	Pseudohypoparathyroidism Ia
AHO	Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Pseudo-Pseudohypoparathyroidism	Pseudohypoparathyroidism Type I A
Php Ia	Pseudopseudohypoparathyroidism
Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance	Pphp
Pseudopseudo-Hypoparathyroidism	Aho-Php Syndrome Ia
Albright Hereditary Osteodystrophy-Php Syndrome Ia	Pseudohypoparathyroidism 1a
Pseudohypoparathyroidism

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Idiopathic Pulmonary Hypertension
Idiopathic Pulmonary Arterial Hypertension	Pulmonary Htn - [Hypertension]

Heel Spur

Calcaneal Spur

Brain Stem Glioma

Brainstem Neuroglial Tumor	Brainstem Glioma
Glioma Of Brainstem

Chronic Pulmonary Heart Disease

Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome

Juvenile Polyposis-Hereditary Hemorrhagic Telangiectasia Syndrome	JPHT
Jp/Hht Syndrome	Juvenile Polyposis With Hereditary Hemorrhagic Telangiectasia
Jps/Hht	Telangiectasia, Hereditary Hemorrhagic, With Juvenile Polyposis Coli
Polyposis, Generalized Juvenile, With Pulmonary Arteriovenous Malformation	Jp-Hht
JP/HHT	Polyposis, Juvenile/Hereditary Hemorrhagic Telangiectasia Syndrome

Camurati-Engelmann Disease

Progressive Diaphyseal Dysplasia	Ced
Engelmann Disease	Diaphyseal Dysplasia 1, Progressive
Pdd	Diaphyseal Dysplasia
Dpd1	Camurati-Engelmann Syndrome
CAEND	Engelman'S Disease
Diaphyseal Hyperostosis	Diaphyseal Osteosclerosis

Ankylosis

Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a

Multiple Pterygium Syndrome, Autosomal Dominant	CPSFS1A
Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a	Autosomal Dominant Disease
Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a	Cpskf1a
Pterygium Syndrome, Multiple	Autosomal Dominant
Arthrogryposis, Distal, Type 8, Formerly	Da8, Formerly
Autosomal Dominant Multiple Pterygium Syndrome	Distal Arthrogryposis Type 8
Arthrogryposis, Distal, Type 8	Da8
Pterygium Syndrome, Multiple, Autosomal Dominant	Autosomal Dominant Disorder

Myositis Ossificans

Myisitis Ossificans

Ossification - Muscle

Synostoses, Tarsal, Carpal, And Digital

Calcaneonavicular Coalition	Multiple Synostosis Syndrome
Synostoses, Tarsal, Carpal And Digital

Histone Mutated Tumor

Histone Mutated Tumour

Joubert Syndrome 21

JBTS21

Joubert Syndrome, Type 21

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach	Stomach Adenocarcinoma
Adenocarcinoma Gastric	Intestinal Type Adenocarcinoma Of Unspecified Site
Diffuse Type Adenocarcinoma Of Unspecified Site

Osseous Heteroplasia, Progressive

Progressive Osseous Heteroplasia	POH
Osteoma Cutis	Familial Ectopic Ossification
Ectopic Ossification Familial Type	Ectopic Ossification
Heterotopic Ossification	Ectopic Ossification, Familial
Cutaneous Ossification	Myositis Ossificans Progressiva
Osteodermia	Osteosis Cutis
Ossification Heterotopic	Heteroplasia, Osseous, Progressive
Fibrodysplasia Ossificans Progressiva

Tarsal-Carpal Coalition Syndrome

TCC	Tarsal Carpal Coalition Syndrome
Nog-Related-Symphalangism Spectrum Disorder

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Brachydactyly, Type B2

Brachydactyly Type B2	BDB2
Brachydactyly B2

Arteriovenous Malformation

Arteriovenous Malformations	Arteriovenous Hemangioma
Cirsoid Aneurysm	Racemose Aneurysm
Racemose Angioma	Racemose Hemangioma
Congenital Arteriovenous Malformation

Hemochromatosis Type 2

Juvenile Hemochromatosis	Juvenile Hereditary Hemochromatosis
Hfe2	Jhh
Hemochromatosis Juvenile	Iron Overload Disease Juvenile
Hemochromatosis, Juvenile	Hemochromatosis, Type 2
Hemochromatosis	Hemochromatosis, Type 1

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109179	Itacnosertib	Inhibitor	99.06%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990022	Prafnosbart	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109179A	Itacnosertib (hydrocholide)	Inhibitor	99.43%	Unkown
HY-RS00236	ACVR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00237	Acvr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00238	Acvr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00239	ACVR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00240	Acvr1b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00241	Acvr1b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00242	ACVR1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00243	Acvr1c Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00244	Acvr1c Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W064657	Momelotinib dihydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ACVR1	VGNC	VGNC:37561
Mus musculus	ACVR1	MGD	MGI:87911
Macaca mulatta	ACVR1	VGNC	VGNC:69438
Rattus norvegicus	ACVR1	RGD	RGD:620200
Felis catus	ACVR1	VGNC	VGNC:59562
Bos taurus	ACVR1	VGNC	VGNC:25592
Macaca fascicularis	ACVR1	NCBI	NCBI:102134051
Others	ACVR1	NCBI