2. Gene
  3. UNC5A - unc-5 netrin receptor A Gene

UNC5A - unc-5 netrin receptor A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UNC5H1

Gene ID: 90249 | Gene type: protein coding

About UNC5A

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,810,559-176,880,898 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 4 paralogues. Biased expression in brain (RPKM 7.1) and adrenal (RPKM 2.6).

Summary

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

UNC5A Products(1)

mRNA Protein Name
NM_133369.3 NP_588610.2 netrin receptor UNC5A precursor

UNC5A Protein Structure

I-set

I-set: Immunoglobulin I-set domain (150 - 238)

ZU5

ZU5: ZU5 domain (441 - 540)

Death

Death: Death domain (763 - 832)

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  • 842 a.a.
Protein Preferred Names Protein Names

netrin receptor UNC5A

netrin receptor Unc5h1

Recombinant UNC5A Proteins

Cat. No. Product Name Accession Purity
HY-P76692 UNC5H1 Protein, Human (HEK293, Fc) Q6ZN44-1/NP_588610.2 (Q26-Y306) ≥95%
HY-P76693 UNC5H1 Protein, Human (HEK293, His) Q6ZN44-1/NP_588610.2 (Q26-Y306) ≥95%

Related Diseases

Diseases Alias
Tonne-Kalscheuer Syndrome

TOKAS

Mrx61

Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia

Mental Retardation, X-Linked 61

X-Linked Mental Retardation 61
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15471 UNC5A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UNC5A VGNC VGNC:48139
Rattus norvegicus UNC5A RGD RGD:621755
Mus musculus UNC5A MGD MGI:894682
Felis catus UNC5A VGNC VGNC:66828
Bos taurus UNC5A VGNC VGNC:36670
Macaca mulatta UNC5A VGNC VGNC:78721
Others UNC5A NCBI