UNC5H1 Protein, Human (HEK293, His)

UNC5H1, a netrin receptor, critically guides axons, promoting neurite outgrowth in response to NTN1. It mediates axon repulsion in growth cones and induces apoptosis when unbound to netrin. UNC5H1 forms homodimers, homooligomers, and interacts with DCC, MAGED1, PRKCABP, FLRT2, and FLRT3, highlighting its multifaceted role in axon guidance and apoptosis during neural development. UNC5H1 Protein, Human (HEK293, His) is the recombinant human-derived UNC5H1 protein, expressed by HEK293 , with C-His labeled tag.

UNC5H1 serves as a pivotal receptor for netrin, playing a crucial role in axon guidance and promoting neurite outgrowth in response to NTN1. Within the netrin signaling pathway, it functions to mediate axon repulsion in neuronal growth cones during nervous system development in response to netrin. The association with DCC is implicated in triggering signaling pathways leading to axon repulsion. Additionally, UNC5H1 acts as a dependence receptor, inducing apoptosis when not bound to netrin ligand. The receptor forms homodimers and homooligomers and interacts with various proteins, including the cytoplasmic part of DCC, MAGED1, PRKCABP, FLRT2, and FLRT3. These intricate interactions underscore UNC5H1's multifaceted role in orchestrating axon guidance and apoptotic responses in neural development.

Human

HEK293

C-His

Q6ZN44-1/NP_588610.2 (Q26-Y306)

90249  [NCBI]

Approximately 32.7 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.