TICRR - TOPBP1 interacting checkpoint and replication regulator Gene

Homo sapiens

Also known as SLD3; Treslin; C15orf42

Gene ID: 90381 | Gene type: protein coding

About TICRR

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,575,469-89,628,023 (from NCBI)

This gene has 3 transcripts (splice variants) and 196 orthologues. Broad expression in bone marrow (RPKM 1.6), testis (RPKM 1.3) and 20 other tissues.

Summary

Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

TICRR Products(2)

mRNA	Protein	Name
NM_001308025.1	NP_001294954.1	treslin isoform 1
NM_152259.4	NP_689472.3	treslin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20080954	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20080954	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of DNA-templated DNA replication initiation	IMP IMP: Inferred from mutant phenotype	20116089	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20080954	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TICRR Protein Structure

Treslin_N

0
300
600
900
1200
1500
1800
1910 a.a.

Protein Preferred Names

Protein Names

treslin

topBP1-interacting checkpoint and replication regulator

Related Diseases

Diseases

Alias

Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type	VEODS
Mrxsveod	Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type
X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14519	TICRR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TICRR	VGNC	VGNC:66183
Canis familiaris	TICRR	VGNC	VGNC:47365
Rattus norvegicus	TICRR	RGD	RGD:1308541
Mus musculus	TICRR	MGD	MGI:1924261
Bos taurus	TICRR	VGNC	VGNC:35860
Macaca mulatta	TICRR	VGNC	VGNC:99272

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