CCNT2 - cyclin T2 Gene

Homo sapiens

Also known as CYCT2

Gene ID: 905 | Gene type: protein coding

About CCNT2

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:134,918,822-134,959,342 (from NCBI)

This gene has 10 transcripts (splice variants), 293 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

CCNT2 Products(4)

mRNA	Protein	Name
NM_001241.4	NP_001232.1	cyclin-T2 isoform a
NM_001320748.2	NP_001307677.1	cyclin-T2 isoform d
NM_001320749.2	NP_001307678.1	cyclin-T2 isoform e
NM_058241.3	NP_490595.1	cyclin-T2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	11713533	GOA
enables RNA polymerase binding	IPI IPI: Inferred from physical interaction	15563843	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9499409	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16331689	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	12037672	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in early viral transcription	IDA IDA: Inferred from direct assay	21509660	GOA
involved in late viral transcription	IDA IDA: Inferred from direct assay	21509660	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15563843	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9499409	GOA
involved in regulation of muscle cell differentiation	IDA IDA: Inferred from direct assay	16331689	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: Inferred from direct assay	9499409	GOA
part of cyclin/CDK positive transcription elongation factor complex	IPI IPI: Inferred from physical interaction	9499409	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9499409	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNT2 Protein Structure

Cyclin_N

0
200
400
600
730 a.a.

Protein Preferred Names

Protein Names

cyclin-T2

SDS-stable vimentin-bound DNA fragment HEF42VIM22

Related Diseases

Diseases

Alias

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02142	CCNT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCNT2	VGNC	VGNC:38907
Rattus norvegicus	CCNT2	RGD	RGD:1309205
Felis catus	CCNT2	VGNC	VGNC:60568
Macaca mulatta	CCNT2	VGNC	VGNC:70736
Bos taurus	CCNT2	VGNC	VGNC:26979
Mus musculus	CCNT2	MGD	MGI:1920199
Others	CCNT2	NCBI

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