2. Gene
  3. RGN - regucalcin Gene

RGN - regucalcin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RC; GNL; SMP30; HEL-S-41

Gene ID: 9104 | Gene type: protein coding

About RGN

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,078,443-47,093,313 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Biased expression in liver (RPKM 68.0), adrenal (RPKM 65.2) and 11 other tissues.

Summary

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RGN Products(4)

mRNA Protein Name
NM_001282848.2 NP_001269777.1 regucalcin isoform 2
NM_001282849.2 NP_001269778.1 regucalcin isoform 3
NM_004683.6 NP_004674.1 regucalcin isoform 1
NM_152869.4 NP_690608.1 regucalcin isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
20329768 GOA
enables gluconolactonase activity IDA
IDA: Inferred from direct assay
20329768 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
20329768 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGN Protein Structure

SGL

SGL: SMP-30/Gluconolaconase/LRE-like region (16 - 263)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

regucalcin

epididymis secretory protein Li 41

Related Diseases

Diseases Alias
Aging
Hypoascorbemia

Scurvy

Ascorbic Acid Deficiency

Vitamin C Deficiency

Vitamin C, Inability To Synthesize

Deficiency Of Vitamin C

Scorbutus

Vitamin C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11896 RGN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RGN VGNC VGNC:76912
Canis familiaris RGN VGNC VGNC:45516
Felis catus RGN VGNC VGNC:97604
Mus musculus RGN MGD MGI:108024
Bos taurus RGN VGNC VGNC:33907
Rattus norvegicus RGN RGD RGD:3560
Others RGN NCBI