PDCD5 - programmed cell death 5 Gene

Homo sapiens

Also known as TFAR19

Gene ID: 9141 | Gene type: protein coding

About PDCD5

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:32,581,190-32,587,453 (from NCBI)

This gene has 8 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in testis (RPKM 17.5), adrenal (RPKM 13.5) and 25 other tissues.

Summary

This gene encodes a protein that is upregulated during Apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

PDCD5 Products(1)

mRNA	Protein	Name
NM_004708.4	NP_004699.1	programmed cell death protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyltransferase activator activity	IDA IDA: Inferred from direct assay	24012345	GOA
enables beta-tubulin binding	IPI IPI: Inferred from physical interaction	24375412	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	17165023	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24012345	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	24012345	GOA
involved in negative regulation of chaperone-mediated protein folding	IMP IMP: Inferred from mutant phenotype	24375412	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9920759	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	24012345	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16374546	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24012345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD5 Protein Structure

dsDNA_bind

0
100
125 a.a.

Protein Preferred Names

Protein Names

programmed cell death protein 5

TF-1 cell apoptosis-related protein 19

PDCD5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDCD5	O14737	TRIM35	Homo sapiens	Q9UPQ4-2	Validated Y2H	32296183
Intra	PDCD5	O14737	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Prey Pooling	32296183
Intra	PDCD5	O14737	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Array	32296183
Intra	PDCD5	O14737	RAD18	Homo sapiens	Q9NS91	Validated Y2H	32296183
Intra	PDCD5	O14737	RAD18	Homo sapiens	Q9NS91	Y2H Array	32296183
Intra	PDCD5	O14737	RAD18	Homo sapiens	Q9NS91	Y2H Prey Pooling	32296183
Intra	PDCD5	O14737	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	PDCD5	O14737	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	PDCD5	O14737	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71019	PDCD5 Protein, Human (His)	O14737 (M1-Y125)	≥95%

Related Diseases

Diseases

Alias

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10193	PDCD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDCD5	MGD	MGI:1913538
Rattus norvegicus	PDCD5	RGD	RGD:1310561
Bos taurus	PDCD5	VGNC	VGNC:32662
Felis catus	PDCD5	VGNC	VGNC:68745
Canis familiaris	PDCD5	VGNC	VGNC:44339
Others	PDCD5	NCBI

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