1. Gene
  2. PICK1 - protein interacting with PRKCA 1 Gene

PICK1 - protein interacting with PRKCA 1 Gene

Homo sapiens

Also known as PICK; PRKCABP

Gene ID: 9463 | Gene type: protein coding

About PICK1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,057,255-38,075,701 (from NCBI)

This gene has 15 transcripts (splice variants), 201 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 10.0), testis (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

PICK1 Products(3)

mRNA Protein Name
NM_001039583.1 NP_001034672.1 PRKCA-binding protein
NM_001039584.1 NP_001034673.1 PRKCA-binding protein
NM_012407.4 NP_036539.1 PRKCA-binding protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables membrane curvature sensor activity IDA
IDA: Inferred from direct assay
29768204 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11343649 GOA
Biological Process GO Annotation Evidence Reference Source
involved in monoamine transport IDA
IDA: Inferred from direct assay
11343649 GOA
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
29768204 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11343649 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11343649 GOA
located in presynaptic membrane IDA
IDA: Inferred from direct assay
11343649 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PICK1 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (23 - 99)

Arfaptin

Arfaptin: Arfaptin-like domain (117 - 352)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
Protein Preferred Names Protein Names

PRKCA-binding protein

protein interacting with C kinase 1

PICK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PICK1 Q9NRD5 CCDC102B Homo sapiens Q68D86 32296183
Intra
PICK1 Q9NRD5 CCDC102B Homo sapiens Q68D86 32296183
Intra
PICK1 Q9NRD5 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
PICK1 Q9NRD5 NECAB2 Homo sapiens Q7Z6G3-2 32296183
Intra
PICK1 Q9NRD5 NECAB2 Homo sapiens Q7Z6G3-2 32296183
Intra
PICK1 Q9NRD5 ZSCAN21 Homo sapiens Q9Y5A6 32296183
Intra
PICK1 Q9NRD5 ZNF524 Homo sapiens Q96C55 32296183
Intra
PICK1 Q9NRD5 MORF4L1 Homo sapiens Q9UBU8-2 32296183
Intra
PICK1 Q9NRD5 PBX4 Homo sapiens Q9BYU1 32296183
Intra
PICK1 Q9NRD5 PBX4 Homo sapiens Q9BYU1 32296183
Intra
PICK1 Q9NRD5 TXNL4B Homo sapiens Q9NX01 32296183
Intra
PICK1 Q9NRD5 POLL Homo sapiens Q9UGP5-2 32296183
Intra
PICK1 Q9NRD5 CACNA1C Homo sapiens Q13936 21653829
Intra
PICK1 Q9NRD5 CACNA1C Homo sapiens Q13936 21653829
Intra
PICK1 Q9NRD5 TSN Homo sapiens Q15631 32296183
Intra
PICK1 Q9NRD5 TSN Homo sapiens Q15631 32296183
Intra
PICK1 Q9NRD5 TSC1 Homo sapiens Q92574 21653829
Intra
PICK1 Q9NRD5 TSC1 Homo sapiens Q92574 21653829
Intra
PICK1 Q9NRD5 CDK2AP1 Homo sapiens O14519 32296183
Intra
PICK1 Q9NRD5 CDK2AP1 Homo sapiens O14519 32296183
Intra
PICK1 Q9NRD5 REL Homo sapiens Q04864-2 32296183
Intra
PICK1 Q9NRD5 REL Homo sapiens Q04864-2 32296183
Intra
PICK1 Q9NRD5 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
PICK1 Q9NRD5 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
PICK1 Q9NRD5 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
PICK1 Q9NRD5 TRIML2 Homo sapiens Q8N7C3 32296183
Intra
PICK1 Q9NRD5 TRIML2 Homo sapiens Q8N7C3 32296183
Intra
PICK1 Q9NRD5 ARX Homo sapiens Q96QS3 21653829
Intra
PICK1 Q9NRD5 ARX Homo sapiens Q96QS3 21653829
Intra
PICK1 Q9NRD5 MSS51 Homo sapiens Q4VC12 32296183
Intra
PICK1 Q9NRD5 MSS51 Homo sapiens Q4VC12 32296183
Intra
PICK1 Q9NRD5 TLE5 Homo sapiens Q08117-2 32296183
Intra
PICK1 Q9NRD5 TLE5 Homo sapiens Q08117-2 32296183
Intra
PICK1 Q9NRD5 LCN2 Homo sapiens P80188 32296183
Intra
PICK1 Q9NRD5 LCN2 Homo sapiens P80188 32296183
Intra
PICK1 Q9NRD5 SHFL Homo sapiens Q9NUL5-4 32296183
Intra
PICK1 Q9NRD5 LRRC73 Homo sapiens Q5JTD7 32296183
Intra
PICK1 Q9NRD5 LRRC73 Homo sapiens Q5JTD7 32296183
Intra
PICK1 Q9NRD5 CPNE7 Homo sapiens Q9UBL6-2 32296183
Intra
PICK1 Q9NRD5 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
PICK1 Q9NRD5 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
PICK1 Q9NRD5 GPATCH2 Homo sapiens Q9NW75-2 28514442
Intra
PICK1 Q9NRD5 GPATCH2 Homo sapiens Q9NW75-2 32296183
Intra
PICK1 Q9NRD5 LZTS1 Homo sapiens Q9Y250 32296183
Intra
PICK1 Q9NRD5 LZTS1 Homo sapiens Q9Y250 32296183
Intra
PICK1 Q9NRD5 LZTS1 Homo sapiens Q9Y250 32296183
Intra
PICK1 Q9NRD5 FAM219B Homo sapiens Q5XKK7 32296183
Intra
PICK1 Q9NRD5 GRB10 Homo sapiens Q13322-4 32296183
Intra
PICK1 Q9NRD5 GRB10 Homo sapiens Q13322-4 32296183
Intra
PICK1 Q9NRD5 ALKBH8 Homo sapiens Q96BT7-2 32296183
Intra
PICK1 Q9NRD5 ALKBH8 Homo sapiens Q96BT7-2 32296183
Intra
PICK1 Q9NRD5 ROPN1 Homo sapiens Q9HAT0 32296183
Intra
PICK1 Q9NRD5 ROPN1 Homo sapiens Q9HAT0 32296183
Intra
PICK1 Q9NRD5 REEP6 Homo sapiens Q96HR9-2 32296183
Intra
PICK1 Q9NRD5 REEP6 Homo sapiens Q96HR9-2 32296183
Intra
PICK1 Q9NRD5 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
PICK1 Q9NRD5 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
PICK1 Q9NRD5 SHANK3 Homo sapiens Q9BYB0 21653829
Intra
PICK1 Q9NRD5 SHANK3 Homo sapiens Q9BYB0 21653829
Intra
PICK1 Q9NRD5 TRIM54 Homo sapiens Q9BYV2 32296183
Intra
PICK1 Q9NRD5 TRIM54 Homo sapiens Q9BYV2 32296183
Intra
PICK1 Q9NRD5 EFHC2 Homo sapiens Q5JST6 32296183
Intra
PICK1 Q9NRD5 EFHC2 Homo sapiens Q5JST6 32296183
Intra
PICK1 Q9NRD5 KCTD6 Homo sapiens Q8NC69 32296183
Intra
PICK1 Q9NRD5 KCTD6 Homo sapiens Q8NC69 32296183
Intra
PICK1 Q9NRD5 SSNA1 Homo sapiens O43805 32296183
Intra
PICK1 Q9NRD5 SSNA1 Homo sapiens O43805 32296183
Intra
PICK1 Q9NRD5 ZBTB2 Homo sapiens Q8N680 32296183
Intra
PICK1 Q9NRD5 ZBTB2 Homo sapiens Q8N680 32296183
Intra
PICK1 Q9NRD5 HSF2 Homo sapiens Q03933 32296183
Intra
PICK1 Q9NRD5 HSF2 Homo sapiens Q03933 32296183
Intra
PICK1 Q9NRD5 FBXL3 Homo sapiens Q9UKT7 32296183
Intra
PICK1 Q9NRD5 ABT1 Homo sapiens Q9ULW3 32296183
Intra
PICK1 Q9NRD5 PKNOX2 Homo sapiens Q96KN3 32296183
Intra
PICK1 Q9NRD5 PKNOX2 Homo sapiens Q96KN3 32296183
Intra
PICK1 Q9NRD5 LZTFL1 Homo sapiens Q9NQ48 32296183
Intra
PICK1 Q9NRD5 LZTFL1 Homo sapiens Q9NQ48 32296183
Intra
PICK1 Q9NRD5 ARMCX1 Homo sapiens Q9P291 32296183
Intra
PICK1 Q9NRD5 MRNIP Homo sapiens Q6NTE8 32296183
Intra
PICK1 Q9NRD5 MRNIP Homo sapiens Q6NTE8 32296183
Intra
PICK1 Q9NRD5 XPA Homo sapiens P23025 32296183
Intra
PICK1 Q9NRD5 DMD Homo sapiens P11532 32296183
Intra
PICK1 Q9NRD5 DMD Homo sapiens P11532 32296183
Intra
PICK1 Q9NRD5 TBC1D7 Homo sapiens Q9P0N9 32296183
Intra
PICK1 Q9NRD5 KIAA1328 Homo sapiens Q86T90 32296183
Intra
PICK1 Q9NRD5 KIAA1328 Homo sapiens Q86T90 32296183
Intra
PICK1 Q9NRD5 CDC42EP2 Homo sapiens O14613 32296183
Intra
PICK1 Q9NRD5 CDC42EP2 Homo sapiens O14613 32296183
Intra
PICK1 Q9NRD5 UACA Homo sapiens Q9BZF9 33961781
Intra
PICK1 Q9NRD5 UACA Homo sapiens Q9BZF9 28514442
Intra
PICK1 Q9NRD5 UACA Homo sapiens Q9BZF9 31413325
Intra
PICK1 Q9NRD5 PSME3 Homo sapiens P61289 32296183
Intra
PICK1 Q9NRD5 PSME3 Homo sapiens P61289 32296183
Intra
PICK1 Q9NRD5 ZNF330 Homo sapiens Q9Y3S2 32296183
Intra
PICK1 Q9NRD5 RIMS3 Homo sapiens Q9UJD0 32296183
Intra
PICK1 Q9NRD5 NMNAT1 Homo sapiens Q9HAN9 32296183
Intra
PICK1 Q9NRD5 NMNAT1 Homo sapiens Q9HAN9 32296183
Intra
PICK1 Q9NRD5 THAP6 Homo sapiens Q8TBB0 32296183
Intra
PICK1 Q9NRD5 THAP6 Homo sapiens Q8TBB0 32296183
Intra
PICK1 Q9NRD5 TSC2 Homo sapiens P49815 21653829
Intra
PICK1 Q9NRD5 TSC2 Homo sapiens P49815 21653829
Intra
PICK1 Q9NRD5 KCTD9 Homo sapiens Q7L273 32296183
Intra
PICK1 Q9NRD5 KCTD9 Homo sapiens Q7L273 32296183
Intra
PICK1 Q9NRD5 BLOC1S2 Homo sapiens Q6QNY1 32296183
Intra
PICK1 Q9NRD5 BLOC1S2 Homo sapiens Q6QNY1 32296183
Intra
PICK1 Q9NRD5 SLX9 Homo sapiens Q9NSI2 32296183
Intra
PICK1 Q9NRD5 YPEL2 Homo sapiens Q96QA6 32296183
Intra
PICK1 Q9NRD5 SMARCA2 Homo sapiens P51531 21653829
Intra
PICK1 Q9NRD5 SMARCA2 Homo sapiens P51531 21653829
Intra
PICK1 Q9NRD5 PTEN Homo sapiens P60484 21653829
Intra
PICK1 Q9NRD5 PTEN Homo sapiens P60484 21653829
Intra
PICK1 Q9NRD5 RXRG Homo sapiens P48443 32296183
Intra
PICK1 Q9NRD5 RXRG Homo sapiens P48443 32296183
Intra
PICK1 Q9NRD5 PNO1 Homo sapiens Q9NRX1 32296183
Intra
PICK1 Q9NRD5 DRAP1 Homo sapiens Q14919 32296183
Intra
PICK1 Q9NRD5 DRAP1 Homo sapiens Q14919 32296183
Intra
PICK1 Q9NRD5 ID2 Homo sapiens Q02363 32296183
Intra
PICK1 Q9NRD5 ID2 Homo sapiens Q02363 32296183
Intra
PICK1 Q9NRD5 ARL6IP1 Homo sapiens Q15041 32296183
Intra
PICK1 Q9NRD5 ARL6IP1 Homo sapiens Q15041 32296183
Intra
PICK1 Q9NRD5 CUTC Homo sapiens Q9NTM9 32296183
Intra
PICK1 Q9NRD5 CUTC Homo sapiens Q9NTM9 32296183
Intra
PICK1 Q9NRD5 CUTC Homo sapiens Q9NTM9 32296183
Intra
PICK1 Q9NRD5 ATP5IF1 Homo sapiens Q9UII2 32296183
Intra
PICK1 Q9NRD5 ATP5IF1 Homo sapiens Q9UII2 32296183
Intra
PICK1 Q9NRD5 ATP5IF1 Homo sapiens Q9UII2 32296183
Intra
PICK1 Q9NRD5 DNMT1 Homo sapiens P26358 21653829
Intra
PICK1 Q9NRD5 DNMT1 Homo sapiens P26358 21653829
Intra
PICK1 Q9NRD5 CGGBP1 Homo sapiens Q9UFW8 32296183
Intra
PICK1 Q9NRD5 MAPRE3 Homo sapiens Q9UPY8 32296183
Intra
PICK1 Q9NRD5 DCTD Homo sapiens P32321 32296183
Intra
PICK1 Q9NRD5 DCTD Homo sapiens P32321 32296183
Intra
PICK1 Q9NRD5 ZBED1 Homo sapiens O96006 32296183
Intra
PICK1 Q9NRD5 ZBED1 Homo sapiens O96006 32296183
Intra
PICK1 Q9NRD5 PCBD1 Homo sapiens P61457 32296183
Intra
PICK1 Q9NRD5 PCBD1 Homo sapiens P61457 32296183
Intra
PICK1 Q9NRD5 HMG20A Homo sapiens Q9NP66 32296183
Intra
PICK1 Q9NRD5 HMG20A Homo sapiens Q9NP66 32296183
Intra
PICK1 Q9NRD5 HSD17B14 Homo sapiens Q9BPX1 32296183
Intra
PICK1 Q9NRD5 HSD17B14 Homo sapiens Q9BPX1 32296183
Intra
PICK1 Q9NRD5 MAGEA4 Homo sapiens P43358 32296183
Intra
PICK1 Q9NRD5 MAGEA4 Homo sapiens P43358 32296183
Intra
PICK1 Q9NRD5 TDO2 Homo sapiens P48775 32296183
Intra
PICK1 Q9NRD5 TDO2 Homo sapiens P48775 32296183
Intra
PICK1 Q9NRD5 NME7 Homo sapiens Q9Y5B8 32296183
Intra
PICK1 Q9NRD5 RPIA Homo sapiens P49247 32296183
Intra
PICK1 Q9NRD5 RPIA Homo sapiens P49247 32296183
Intra
PICK1 Q9NRD5 GPKOW Homo sapiens Q92917 32296183
Intra
PICK1 Q9NRD5 PAX6 Homo sapiens P26367 32296183
Intra
PICK1 Q9NRD5 PAX6 Homo sapiens P26367 32296183
Intra
PICK1 Q9NRD5 SERTAD1 Homo sapiens Q9UHV2 32296183
Intra
PICK1 Q9NRD5 SERTAD1 Homo sapiens Q9UHV2 32296183
Intra
PICK1 Q9NRD5 SERTAD1 Homo sapiens Q9UHV2 32296183
Intra
PICK1 Q9NRD5 SERTAD3 Homo sapiens Q9UJW9 32296183
Intra
PICK1 Q9NRD5 SERTAD3 Homo sapiens Q9UJW9 32296183
Intra
PICK1 Q9NRD5 SERTAD3 Homo sapiens Q9UJW9 32296183
Intra
PICK1 Q9NRD5 SH3GLB2 Homo sapiens Q9NR46 32296183
Intra
PICK1 Q9NRD5 SH3GLB2 Homo sapiens Q9NR46 32296183
Intra
PICK1 Q9NRD5 INO80E Homo sapiens Q8NBZ0 32296183
Intra
PICK1 Q9NRD5 INO80E Homo sapiens Q8NBZ0 32296183
Intra
PICK1 Q9NRD5 ASIC2 Homo sapiens Q16515 11802773
Intra
PICK1 Q9NRD5 ASIC1 Homo sapiens P78348 33961781
Intra
PICK1 Q9NRD5 ASIC1 Homo sapiens P78348 11802773
Intra
PICK1 Q9NRD5 ASIC1 Homo sapiens P78348 11802773
Intra
PICK1 Q9NRD5 FAM9A Homo sapiens Q8IZU1 32296183
Intra
PICK1 Q9NRD5 FAM9A Homo sapiens Q8IZU1 32296183
Intra
PICK1 Q9NRD5 HOXA5 Homo sapiens P20719 32296183
Intra
PICK1 Q9NRD5 OARD1 Homo sapiens Q9Y530 32296183
Intra
PICK1 Q9NRD5 IHO1 Homo sapiens Q8IYA8 32296183
Intra
PICK1 Q9NRD5 IHO1 Homo sapiens Q8IYA8 32296183
Intra
PICK1 Q9NRD5 AVPI1 Homo sapiens Q5T686 32296183
Intra
PICK1 Q9NRD5 AVPI1 Homo sapiens Q5T686 32296183
Intra
PICK1 Q9NRD5 TTC23L Homo sapiens Q6PF05 32296183
Intra
PICK1 Q9NRD5 TTC23L Homo sapiens Q6PF05 32296183
Intra
PICK1 Q9NRD5 TRIM44 Homo sapiens Q96DX7 32296183
Intra
PICK1 Q9NRD5 TRIM44 Homo sapiens Q96DX7 32296183
Intra
PICK1 Q9NRD5 TBC1D22B Homo sapiens Q9NU19 32296183
Intra
PICK1 Q9NRD5 KCTD1 Homo sapiens Q719H9 32296183
Intra
PICK1 Q9NRD5 KCTD1 Homo sapiens Q719H9 32296183
Intra
PICK1 Q9NRD5 OSGIN1 Homo sapiens Q9UJX0 32296183
Intra
PICK1 Q9NRD5 ZNF624 Homo sapiens Q9P2J8 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PICK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81887 PICK1 Antibody (YA1632) WB, IP Human

Related Diseases

Diseases Alias
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

SPGF5

Macrocephalic Sperm Head Syndrome

Male Infertility Due To Macrozoospermia

Infertility Associated With Multitailed Spermatozoa And Excessive Dna

Macrozoospermia

Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

Large-Headed Multiflagellar Polyploid Spermatozoa

Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

Childhood Absence Epilepsy

Pyknolepsy

Petit Mal Epilepsy

Absence Seizures

Absence Seizure

Petit Mal Seizure

Absence Epilepsy, Childhood

Pykno-Epilepsy

Epilepsy, Absence

Absence Epilepsy

Pycnolepsy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PICK1 VGNC VGNC:44525
Rattus norvegicus PICK1 RGD RGD:69437
Macaca mulatta PICK1 VGNC VGNC:76013
Felis catus PICK1 VGNC VGNC:69056
Bos taurus PICK1 VGNC VGNC:32861
Mus musculus PICK1 MGD MGI:894645
Others PICK1 NCBI