2. Gene
  3. ATP23 - ATP23 metallopeptidase and ATP synthase assembly factor homolog Gene

ATP23 - ATP23 metallopeptidase and ATP synthase assembly factor homolog Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KUB3; XRCC6BP1

Gene ID: 91419 | Gene type: protein coding

About ATP23

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,941,567-57,959,148 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele and 206 orthologues. Broad expression in testis (RPKM 13.5), bone marrow (RPKM 4.5) and 24 other tissues.

Summary

The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ATP23 Products(4)

mRNA Protein Name
NM_001320408.2 NP_001307337.1 mitochondrial inner membrane protease ATP23 homolog isoform b
NM_001320409.2 NP_001307338.1 mitochondrial inner membrane protease ATP23 homolog isoform c
NM_001320410.2 NP_001307339.1 mitochondrial inner membrane protease ATP23 homolog isoform c
NM_033276.4 NP_150592.1 mitochondrial inner membrane protease ATP23 homolog isoform a

ATP23 Protein Structure

Peptidase_M76

Peptidase_M76: Peptidase M76 family (50 - 220)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

mitochondrial inner membrane protease ATP23 homolog

Ku70-binding protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01190 ATP23 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATP23 VGNC VGNC:60019
Bos taurus ATP23 VGNC VGNC:26289
Rattus norvegicus ATP23 RGD RGD:1588587
Canis familiaris ATP23 VGNC VGNC:38252
Mus musculus ATP23 MGD MGI:1916984