PKDCC - protein kinase domain containing, cytoplasmic Gene

Homo sapiens

Also known as Vlk; RLSDF; SGK493

Gene ID: 91461 | Gene type: protein coding

About PKDCC

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,048,021-42,058,517 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in ovary (RPKM 28.2), endometrium (RPKM 26.6) and 22 other tissues.

Summary

Enables non-membrane spanning protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation and skeletal system development. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PKDCC Products(1)

mRNA	Protein	Name
NM_138370.3	NP_612379.2	extracellular tyrosine-protein kinase PKDCC precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	25171405	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	25171405	GOA
involved in skeletal system development	IMP IMP: Inferred from mutant phenotype	30478137	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	25171405	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKDCC Protein Structure

PIP49_C

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

extracellular tyrosine-protein kinase PKDCC

protein kinase domain containing, cytoplasmic homolog

Related Diseases

Diseases

Alias

Rhizomelic Limb Shortening With Dysmorphic Features

RLSDF

N Syndrome

NSX	Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia

Amelogenesis Imperfecta, Type Ic

Amelogenesis Imperfecta Type 1c	AI1C
Amelogenesis Imperfecta Type Ic	Amelogenesis Imperfecta, Local Hypoplastic Type, Autosomal Recessive
Amelogenesis Imperfecta, Hypoplastic, With Or Without Open-Bite Malocclusion, Autosomal Recessive	Autosomal Recessive Amelogenesis Imperfecta Hypoplastic With Or Without Openbite Malocclusion
Autosomal Recessive Amelogenesis Imperfecta Local Hypoplastic Type	Amelogenesis Imperfecta 1c
Amelogenesis Imperfecta Hypoplastic With Or Without Openbite Malocclusion Autosomal Recessive	Amelogenesis Imperfecta Local Hypoplastic Type Autosomal Recessive

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10595	PKDCC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PKDCC	VGNC	VGNC:81149
Macaca mulatta	PKDCC	VGNC	VGNC:106196
Canis familiaris	PKDCC	VGNC	VGNC:44603
Mus musculus	PKDCC	MGD	MGI:2147077
Bos taurus	PKDCC	VGNC	VGNC:32938
Rattus norvegicus	PKDCC	RGD	RGD:1311939

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