SLFN11 - schlafen family member 11 Gene

Homo sapiens

Also known as SLFN8/9

Gene ID: 91607 | Gene type: protein coding

About SLFN11

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,350,305-35,373,621 (from NCBI)

This gene has 14 transcripts (splice variants), 108 orthologues and 6 paralogues. Ubiquitous expression in lung (RPKM 14.8), thyroid (RPKM 12.0) and 24 other tissues.

Summary

Enables tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

SLFN11 Products(16)

mRNA	Protein	Name
NM_001104587.2	NP_001098057.1	schlafen family member 11
NM_001104588.2	NP_001098058.1	schlafen family member 11
NM_001104589.2	NP_001098059.1	schlafen family member 11
NM_001104590.2	NP_001098060.1	schlafen family member 11
NM_001376007.1	NP_001362936.1	schlafen family member 11
NM_001376008.1	NP_001362937.1	schlafen family member 11
NM_001376009.1	NP_001362938.1	schlafen family member 11
NM_001376010.1	NP_001362939.1	schlafen family member 11
NM_001376011.1	NP_001362940.1	schlafen family member 11
NM_001387158.1	NP_001374087.1	schlafen family member 11
NM_001387159.1	NP_001374088.1	schlafen family member 11
NM_001387160.1	NP_001374089.1	schlafen family member 11
NM_001387161.1	NP_001374090.1	schlafen family member 11
NM_001387162.1	NP_001374091.1	schlafen family member 11
NM_001387163.1	NP_001374092.1	schlafen family member 11
NM_152270.4	NP_689483.3	schlafen family member 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	29395061	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29395061	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	23000900	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	29395061	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	29395061	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	23000900	GOA
involved in negative regulation of DNA replication	IDA IDA: Inferred from direct assay	29395061	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22927417	GOA
involved in replication fork arrest	IDA IDA: Inferred from direct assay	29395061	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22927417	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	29395061	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLFN11 Protein Structure

AlbA_2

DUF2075

0
200
400
600
800
901 a.a.

Protein Preferred Names

Protein Names

schlafen family member 11

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13363	SLFN11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLFN11	RGD	RGD:1359139

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