COX7A2L - cytochrome c oxidase subunit 7A2 like Gene

Homo sapiens

Also known as EB1; SCAF1; SCAFI; SIG81; COX7AR; COX7RP

Gene ID: 9167 | Gene type: protein coding

About COX7A2L

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,335,559-42,368,957 (from NCBI)

This gene has 8 transcripts (splice variants), 270 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 37.4), kidney (RPKM 24.0) and 25 other tissues.

Summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast Cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and Others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

COX7A2L Products(5)

mRNA	Protein	Name
NM_001319036.1	NP_001305965.1	cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform a
NM_001319037.1	NP_001305966.1	cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform b
NM_001319038.2	NP_001305967.1	cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform c
NM_001319040.2	NP_001305969.1	cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform d
NM_004718.4	NP_004709.2	cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform a

COX7A2L Protein Structure

COX7a

0
100
114 a.a.

Protein Preferred Names

Protein Names

cytochrome c oxidase subunit 7A-related protein, mitochondrial

COX7a-related protein

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03075	COX7A2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COX7A2L	RGD	RGD:1306111
Canis familiaris	COX7A2L	VGNC	VGNC:39541
Mus musculus	COX7A2L	MGD	MGI:106015
Felis catus	COX7A2L	VGNC	VGNC:80075
Bos taurus	COX7A2L	VGNC	VGNC:27640

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