HTR3B - 5-hydroxytryptamine receptor 3B Gene

Homo sapiens

Also known as 5-HT3B

Gene ID: 9177 | Gene type: protein coding

About HTR3B

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,898,923-113,949,079 (from NCBI)

This gene has 3 transcripts (splice variants), 175 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

HTR3B Products(2)

mRNA	Protein	Name
NM_001363563.2	NP_001350492.1	5-hydroxytryptamine receptor 3B isoform 2
NM_006028.5	NP_006019.1	5-hydroxytryptamine receptor 3B isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables serotonin-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	7565620	GOA
enables serotonin-gated monoatomic cation channel activity	IGI IGI: Inferred from genetic interaction	9950429	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	17392525	GOA
involved in serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	17392525	GOA
involved in serotonin-gated cation-selective signaling pathway	IDA IDA: Inferred from direct assay	9950429	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16571125	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21138434	GOA
part of serotonin-activated cation-selective channel complex	IGI IGI: Inferred from genetic interaction	9950429	GOA
part of serotonin-activated cation-selective channel complex	IPI IPI: Inferred from physical interaction	16116092	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR3B Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
441 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 3B

5-hydroxytryptamine (serotonin) receptor 3B, ionotropic

Related Diseases

Diseases

Alias

Motion Sickness

Airsickness	Carsickness
Seasickness	Travel Sickness
Riders' Vertigo

Heroin Dependence

Myasthenic Syndrome, Congenital, 15

Congenital Myasthenic Syndrome 15	CMS15
Myasthenic Syndrome, Congenital, Without Tubular Aggregates	Cmswta
Myasthenic Syndrome, Congenital, 15, Without Tubular Aggregates	Congenital Myasthenic Syndrome 15 Without Tubular Aggregates
Myasthenic Syndrome, Congenital, Type 15, Without Tubular Aggregates

Fibromyalgia

Diffuse Myofascial Pain Syndrome	Fibromyalgia Syndrome
Fibromyalgia-Fibromyositis Syndrome	Fibromyositis
Fibrositis	Fms
Myofascial Pain Syndrome	Myofascial Pain Syndromes

Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 9	CMS9
Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency	Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency

Pigmented Paravenous Chorioretinal Atrophy

Pigmented Paravenous Retinochoroidal Atrophy	PPCRA
Pprca	Atrophy, Chorioretinal, Pigmented Paravenous

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Antisocial Personality Disorder

Dissocial Personality Disorder	Asocial Personality
Psychopath.Personality	Psychopathic Personality
Psychopathic Personality Disorder	Sociopathic Personality

Tobacco Addiction

Nicotine Dependence	Tobacco Addiction, Susceptibility To
Nicotine Addiction	Tobacco Use Disorder
Smoking Habit	Nicotine Dependence, Protection Against
Nicotine Addiction, Protection From	Cigarette Habituation
Cigarette Habituation, Susceptibility To	Smoking Habit, Susceptibility To
Nicotine Dependence, Susceptibility To	Nicotine Addiction, Susceptibility To
Addiction, Tobacco, Susceptibility To	Compulsive Tobacco User Syndrome
Tobacco Dependence	Tobacco Dependence Syndrome
Cigarette Addiction	Cigarette Dependence
Smoking Addiction	Smokers Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06473	HTR3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HTR3B	RGD	RGD:61820
Felis catus	HTR3B	VGNC	VGNC:67674
Canis familiaris	HTR3B	VGNC	VGNC:41830
Macaca mulatta	HTR3B	VGNC	VGNC:73543
Mus musculus	HTR3B	MGD	MGI:1861899
Bos taurus	HTR3B	VGNC	VGNC:29999

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