2. Gene
  3. DTD1 - D-aminoacyl-tRNA deacylase 1 Gene

DTD1 - D-aminoacyl-tRNA deacylase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DTD; DUEB; DUE-B; HARS2; pqn-68; C20orf88

Gene ID: 92675 | Gene type: protein coding

About DTD1

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,588,054-18,766,644 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.0), brain (RPKM 6.2) and 25 other tissues.

Summary

The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

DTD1 Products(2)

mRNA Protein Name
NM_001318043.2 NP_001304972.1 D-aminoacyl-tRNA deacylase 1 isoform 1
NM_080820.6 NP_543010.3 D-aminoacyl-tRNA deacylase 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding EXP
EXP: Inferred from Experiment
17264083 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA duplex unwinding EXP
EXP: Inferred from Experiment
17264083 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTD1 Protein Structure

Tyr_Deacylase

Tyr_Deacylase: D-Tyr-tRNA(Tyr) deacylase (2 - 146)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

D-aminoacyl-tRNA deacylase 1

D-tyrosyl-tRNA deacylase 1 homolog

Recombinant DTD1 Proteins

Cat. No. Product Name Accession Purity
HY-P70087 DTD1 Protein, Human (HEK293, His) Q8TEA8 (M1-P209) ≥95%

Related Diseases

Diseases Alias
Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis

Urbach-Wiethe Disease

Hyalinosis Cutis Et Mucosae

Lipid Proteinosis

Lipoproteinosis

Urbach Wiethe Disease

Lipoglycoproteinosis

Lipoidosis Cutis Et Mucosae

Lipoidproteinosis

Urbach-Wiethe Lipoid Proteinosis

Urbach-Wiethe Syndrome

LIP

Proteinosis Lipoid
Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10

SCA10

Spinocerebellar Ataxia-10

Ataxia, Spinocerebellar, Type 10
Ornithosis

Psittacosis

Chlamydial Pneumonia

Chlamydia Psittaci Infection

Chlamydia Psittaci
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04031 DTD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DTD1 VGNC VGNC:28228
Felis catus DTD1 VGNC VGNC:80088
Macaca mulatta DTD1 VGNC VGNC:84730
Canis familiaris DTD1 VGNC VGNC:103672
Mus musculus DTD1 MGD MGI:1913294
Rattus norvegicus DTD1 RGD RGD:1311821
Others DTD1 NCBI