2. Gene
  3. WDR46 - WD repeat domain 46 Gene

WDR46 - WD repeat domain 46 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UTP7; BING4; FP221; C6orf11

Gene ID: 9277 | Gene type: protein coding

About WDR46

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,279,108-33,289,239 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in appendix (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

WDR46 Products(2)

mRNA Protein Name
NM_001164267.2 NP_001157739.1 WD repeat-containing protein 46 isoform 2
NM_005452.6 NP_005443.3 WD repeat-containing protein 46 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence Reference Source
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR46 Protein Structure

WD40

WD40: WD domain, G-beta repeat (350 - 387)

BING4CT

BING4CT: BING4CT (NUC141) domain (440 - 518)

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  • 500
  • 610 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 46

WD repeat-containing protein BING4

Related Diseases

Diseases Alias
Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps

Asa Triad

Asthma, Aspirin-Induced, Susceptibility To

Asthma, Aspirin-Induced

Asthma, With Nasal Polyps And Aspirin Intolerance

ANPAI

Aia

Aspirin-Intolerant Asthma

Asthma Aspirin-Induced

Nasal Polyps Asthma And Aspirin Sensitivity

Samter Triad

Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15782 WDR46 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta WDR46 VGNC VGNC:78940
Rattus norvegicus WDR46 RGD RGD:2209
Mus musculus WDR46 MGD MGI:1931871
Felis catus WDR46 VGNC VGNC:67036
Canis familiaris WDR46 VGNC VGNC:48369
Bos taurus WDR46 VGNC VGNC:36902