2. Gene
  3. ATP6V1F - ATPase H+ transporting V1 subunit F Gene

ATP6V1F - ATPase H+ transporting V1 subunit F Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VATF; Vma7; ATP6S14

Gene ID: 9296 | Gene type: protein coding

About ATP6V1F

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,862,856-128,865,847 (from NCBI)

This gene has 2 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in kidney (RPKM 97.5), brain (RPKM 77.0) and 25 other tissues.

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

ATP6V1F Products(2)

mRNA Protein Name
NM_001198909.2 NP_001185838.1 V-type proton ATPase subunit F isoform 2
NM_004231.4 NP_004222.2 V-type proton ATPase subunit F isoform 1

ATP6V1F Protein Structure

ATP-synt_F

ATP-synt_F: ATP synthase (F/14-kDa) subunit (8 - 107)

  • 0
  • 100
  • 119 a.a.
Protein Preferred Names Protein Names

V-type proton ATPase subunit F

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F

ATP6V1F Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ATP6V1F Q16864 ATP6V1D Homo sapiens Q9Y5K8
Y2H Prey Pooling
32296183
Intra
ATP6V1F Q16864 ATP6V1D Homo sapiens Q9Y5K8
Anti Tag CoIP
35271311
Intra
ATP6V1F Q16864 ATP6V1D Homo sapiens Q9Y5K8
Validated Y2H
32296183
Intra
ATP6V1F Q16864 ATP6V1D Homo sapiens Q9Y5K8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATP6V1F Proteins

Cat. No. Product Name Accession Purity
HY-P76159 ATP6V1F Protein, Human (GST) Q16864 (M1-R119) ≥95%

Related Diseases

Diseases Alias
Cardiomyopathy, Dilated, 1m

Dilated Cardiomyopathy 1m

CMD1M

Cardiomyopathy, Dilated 1m

Cardiomyopathy, Dilated, Type 1m
Hermansky-Pudlak Syndrome 3

HPS3

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 3

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Non-Syndromic X-Linked Intellectual Disability 2

Mrx2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01230 ATP6V1F Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ATP6V1F VGNC VGNC:38282
Felis catus ATP6V1F VGNC VGNC:60025
Mus musculus ATP6V1F MGD MGI:1913394
Rattus norvegicus ATP6V1F RGD RGD:621552
Bos taurus ATP6V1F VGNC VGNC:107217
Others ATP6V1F NCBI