2. Gene
  3. CD83 - CD83 molecule Gene

CD83 - CD83 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BL11; HB15

Gene ID: 9308 | Gene type: protein coding

About CD83

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:14,117,256-14,136,918 (from NCBI)

This gene has 2 transcripts (splice variants) and 120 orthologues. Broad expression in bone marrow (RPKM 72.2), lymph node (RPKM 25.8) and 14 other tissues.

Summary

The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

CD83 Products(3)

mRNA Protein Name
NM_001040280.3 NP_001035370.1 CD83 antigen isoform b precursor
NM_001251901.1 NP_001238830.1 CD83 antigen isoform c
NM_004233.4 NP_004224.1 CD83 antigen isoform a precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20374249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD83 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (20 - 119)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

CD83 antigen

B-cell activation protein

CD83 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CD83 Q01151 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra CD83 Q01151 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra CD83 Q01151 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD83 Proteins

Cat. No. Product Name Accession Purity
HY-P72703 CD83 Protein, Human (HEK293, Fc) Q01151 (T20-A143) ≥95%
HY-P75377 CD83 Protein, Human (HEK293, His) Q01151 (T20-A143) ≥95%

Related Diseases

Diseases Alias
Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection
Sulfamethoxazole Allergy

Smx Allergy

Smz Allergy

Sulphamethoxazole Allergy
Herpes Zoster

Shingles

Zoster

Herpes Zona

Herpes Zoster Disease

Zona Zoster

Herpes Zoster Of Skin And Mucous Membranes

Zoster Nos

Zoster With Nervous System Involvement
Rift Valley Fever

Rfv - [Rift Valley Fever]
Anal Gland Neoplasm

Anal Gland Neoplasms
Temporal Arteritis

Polymyalgia Rheumatica

Giant Cell Arteritis

Cranial Arteritis

Horton Disease

Gca

Horton'S Disease

Rhizomelic Pseudopolyarthritis

Arteritis Cranialis

Arteritis Temporalis

Horton'S Arteritis

Horton'S Giant Cell Arteritis

Horton'S Temporal Arteritis

Horton'S Syndrome

Gca - [Giant Cell Arteritis]

Senile Arthritis

Polymyalgia Arteritica

Pmr - [Polymyalgia Rheumatica]

Forestier-Certonciny Syndrome

Rheumatic Polymyalgia

Polymyalgia
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction

Left Ventricular Noncompaction 3

Dilated Cardiomyopathy 1c

CMD1C

Cardiomyopathy, Hypertrophic, 24

Dilated Cardiomyopathy With Left Ventricular Noncompaction

Cardiomyopathy, Dilated, 1c, With Or Without Lvnc

Cmdc1

Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction

Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction

Cardiomyopathy Dilated With Left Ventricular Noncompaction

Cardiomyopathy, Familial Hypertrophic 24

CMH24

Left Ventricular Non-Compaction 3

LVNC3

Cardiomyopathy, Dilated 1c

Familial Hypertrophic Cardiomyopathy 24

Cardiomyopathy, Dilated, 1c
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02272 CD83 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CD83 VGNC VGNC:38977
Mus musculus CD83 MGD MGI:1328316
Felis catus CD83 VGNC VGNC:60641
Rattus norvegicus CD83 RGD RGD:1309677
Bos taurus CD83 VGNC VGNC:27050
Macaca mulatta CD83 VGNC VGNC:70783
Macaca fascicularis CD83 NCBI NCBI:102133406
Others CD83 NCBI