FATE1 - fetal and adult testis expressed 1 Gene

Homo sapiens

Also known as CT43; FATE

Gene ID: 89885 | Gene type: protein coding

About FATE1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,716,035-151,723,194 (from NCBI)

This gene has 2 transcripts (splice variants) and 77 orthologues. Restricted expression toward testis (RPKM 120.2).

Summary

This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]

FATE1 Products(1)

mRNA	Protein	Name
NM_033085.3	NP_149076.1	fetal and adult testis-expressed transcript protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	26567849	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12865919	GOA
involved in negative regulation of mitochondrial calcium ion concentration	IDA IDA: Inferred from direct assay	12865919	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	12865919	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	12865919	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FATE1 Protein Structure

Miff

0
100
183 a.a.

Protein Preferred Names

Protein Names

fetal and adult testis-expressed transcript protein

BJ-HCC-2 antigen

Related Diseases

Diseases

Alias

Martin-Probst Syndrome

Deafness-Intellectual Disability, Martin-Probst Type Syndrome	Martin-Probst Deafness-Mental Retardation Syndrome
Mental Retardation, X-Linked, Syndromic, Martin-Probst Type	MRXSMP
Deafness-Intellectual Disability Syndrome, Martin-Probst Type	Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type
X-Linked Deafness-Intellectual Disability Syndrome Syndrome	X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04764	FATE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FATE1	VGNC	VGNC:28878
Felis catus	FATE1	VGNC	VGNC:62160
Mus musculus	FATE1	MGD	MGI:1925155
Canis familiaris	FATE1	VGNC	VGNC:40746

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