2. Gene
  3. FATE1 - fetal and adult testis expressed 1 Gene

FATE1 - fetal and adult testis expressed 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CT43; FATE

Gene ID: 89885 | Gene type: protein coding

About FATE1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,716,035-151,723,194 (from NCBI)

This gene has 2 transcripts (splice variants) and 77 orthologues. Restricted expression toward testis (RPKM 120.2).

Summary

This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and Other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]

FATE1 Products(1)

mRNA Protein Name
NM_033085.3 NP_149076.1 fetal and adult testis-expressed transcript protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
26567849 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12865919 GOA
involved in negative regulation of mitochondrial calcium ion concentration IDA
IDA: Inferred from direct assay
12865919 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
12865919 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
12865919 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FATE1 Protein Structure

Miff

Miff: Mitochondrial and peroxisomal fission factor Mff (29 - 182)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

fetal and adult testis-expressed transcript protein

BJ-HCC-2 antigen

FATE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FATE1 Q969F0 GPR25 Homo sapiens O00155
Validated Y2H
25416956
Intra
FATE1 Q969F0 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
FATE1 Q969F0 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 LY75 Homo sapiens O60449-3
Y2H Array
25416956
Intra
FATE1 Q969F0 SNAP47 Homo sapiens Q5SQN1
Y2H Array
25416956
Intra
FATE1 Q969F0 AQP9 Homo sapiens Q6FGT0
Y2H Array
25416956
Intra
FATE1 Q969F0 NRSN1 Homo sapiens Q8IZ57
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 NRSN1 Homo sapiens Q8IZ57
Validated Y2H
25416956
Intra
FATE1 Q969F0 NRSN1 Homo sapiens Q8IZ57
Y2H Array
25416956
Intra
FATE1 Q969F0 PRRG2 Homo sapiens Q8TAS3
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 PRRG2 Homo sapiens Q8TAS3
Y2H Array
25416956
Intra
FATE1 Q969F0 SYNPR Homo sapiens Q8TBG9
Validated Y2H
25416956
Intra
FATE1 Q969F0 MR1 Homo sapiens Q95460
Validated Y2H
25416956
Intra
FATE1 Q969F0 SLC41A2 Homo sapiens Q96JW4
Validated Y2H
32296183
Intra
FATE1 Q969F0 TMEM74 Homo sapiens Q96NL1
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 SEC22C Homo sapiens Q9BRL7
Validated Y2H
25416956
Intra
FATE1 Q969F0 SEC22C Homo sapiens Q9BRL7
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 MARCHF2 Homo sapiens Q9P0N8
Validated Y2H
32296183
Intra
FATE1 Q969F0 MARCHF2 Homo sapiens Q9P0N8
Y2H Array
25416956
Intra
FATE1 Q969F0 KCNS2 Homo sapiens Q9ULS6
Validated Y2H
25416956
Intra
FATE1 Q969F0 KCNS2 Homo sapiens Q9ULS6
Validated Y2H
32296183
Intra
FATE1 Q969F0 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 RPRM Homo sapiens Q9NS64
Validated Y2H
25416956
Intra
FATE1 Q969F0 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
FATE1 Q969F0 RPRM Homo sapiens Q9NS64
Y2H Array
25416956
Intra
FATE1 Q969F0 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
FATE1 Q969F0 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
FATE1 Q969F0 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 LNPEP Homo sapiens Q9UIQ6-2
Validated Y2H
32296183
Intra
FATE1 Q969F0 CALN1 Homo sapiens Q9BXU9
Validated Y2H
32296183
Intra
FATE1 Q969F0 GINM1 Homo sapiens Q9NU53
Validated Y2H
32296183
Intra
FATE1 Q969F0 PKMYT1 Homo sapiens Q99640-2
Validated Y2H
32296183
Intra
FATE1 Q969F0 NDUFB11 Homo sapiens Q9NX14
Validated Y2H
32296183
Intra
FATE1 Q969F0 NDUFB11 Homo sapiens Q9NX14
Validated Y2H
25416956
Intra
FATE1 Q969F0 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
FATE1 Q969F0 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
FATE1 Q969F0 CSF2RA Homo sapiens P15509
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
FATE1 Q969F0 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
FATE1 Q969F0 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 MARCHF5 Homo sapiens Q9NX47
Y2H Array
25416956
Intra
FATE1 Q969F0 MARCHF5 Homo sapiens Q9NX47
Y2H Array
31515488
Intra
FATE1 Q969F0 USP20 Homo sapiens Q9Y2K6
Validated Y2H
25416956
Intra
FATE1 Q969F0 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
FATE1 Q969F0 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
FATE1 Q969F0 LNPEP Homo sapiens Q9UIQ6
Validated Y2H
25416956
Intra
FATE1 Q969F0 SMIM14 Homo sapiens Q96QK8
Validated Y2H
32296183
Intra
FATE1 Q969F0 SMIM14 Homo sapiens Q96QK8
Y2H
21516116
Intra
FATE1 Q969F0 UNC93B1 Homo sapiens Q9H1C4
Validated Y2H
32296183
Intra
FATE1 Q969F0 FRMD8 Homo sapiens Q9BZ67
Validated Y2H
32296183
Intra
FATE1 Q969F0 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra
FATE1 Q969F0 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
31515488
Intra
FATE1 Q969F0 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
25416956
Intra
FATE1 Q969F0 SYNGR1 Homo sapiens O43759
Y2H Array
25416956
Intra
FATE1 Q969F0 SYNGR1 Homo sapiens O43759
Validated Y2H
25416956
Intra
FATE1 Q969F0 CCDC70 Homo sapiens Q6NSX1
Y2H Array
31515488
Intra
FATE1 Q969F0 CCDC70 Homo sapiens Q6NSX1
Y2H Array
25416956
Intra
FATE1 Q969F0 BIK Homo sapiens Q13323
Y2H Array
25416956
Intra
FATE1 Q969F0 BIK Homo sapiens Q13323
Y2H Array
31515488
Intra
FATE1 Q969F0 BIK Homo sapiens Q13323
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 BIK Homo sapiens Q13323
Validated Y2H
25416956
Intra
FATE1 Q969F0 BCL2L2 Homo sapiens Q92843
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 BCL2L2 Homo sapiens Q92843
Validated Y2H
25416956
Intra
FATE1 Q969F0 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
FATE1 Q969F0 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Intra
FATE1 Q969F0 PIN4 Homo sapiens Q9Y237
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 PIN4 Homo sapiens Q9Y237
Y2H Array
25416956
Intra
FATE1 Q969F0 TMEM11 Homo sapiens P17152
Y2H
21516116
Intra
FATE1 Q969F0 SYNDIG1 Homo sapiens Q9H7V2
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 SYNDIG1 Homo sapiens Q9H7V2
Validated Y2H
32296183
Intra
FATE1 Q969F0 SYNDIG1 Homo sapiens Q9H7V2
Validated Y2H
25416956
Intra
FATE1 Q969F0 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
Intra
FATE1 Q969F0 SEC23B Homo sapiens Q15437
Y2H Array
25416956
Intra
FATE1 Q969F0 RNF183 Homo sapiens Q96D59
Validated Y2H
32296183
Intra
FATE1 Q969F0 RNF183 Homo sapiens Q96D59
Y2H Pooling
16189514
Intra
FATE1 Q969F0 DCTN5 Homo sapiens Q9BTE1
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 DCTN5 Homo sapiens Q9BTE1
Y2H Array
25416956
Intra
FATE1 Q969F0 DCTN5 Homo sapiens Q9BTE1
Validated Y2H
25416956
Intra
FATE1 Q969F0 ZCCHC12 Homo sapiens Q6PEW1
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 ZCCHC12 Homo sapiens Q6PEW1
Y2H Array
32296183
Intra
FATE1 Q969F0 INPP5K Homo sapiens Q9BT40
Validated Y2H
32296183
Intra
FATE1 Q969F0 INPP5K Homo sapiens Q9BT40
Validated Y2H
25416956
Intra
FATE1 Q969F0 INPP5K Homo sapiens Q9BT40
Y2H Array
29892012
Intra
FATE1 Q969F0 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
FATE1 Q969F0 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
25416956
Intra
FATE1 Q969F0 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
Intra
FATE1 Q969F0 YIPF4 Homo sapiens Q9BSR8
Y2H Array
25416956
Intra
FATE1 Q969F0 BNIP2 Homo sapiens Q12982
Validated Y2H
32296183
Intra
FATE1 Q969F0 BNIP2 Homo sapiens Q12982
Y2H Array
25416956
Intra
FATE1 Q969F0 BNIP2 Homo sapiens Q12982
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 BNIP2 Homo sapiens Q12982
Validated Y2H
25416956
Intra
FATE1 Q969F0 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Intra
FATE1 Q969F0 TRAF3IP3 Homo sapiens Q9Y228
Y2H Array
25416956
Intra
FATE1 Q969F0 TRAF3IP3 Homo sapiens Q9Y228
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 BNIP3L Homo sapiens O60238
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra
FATE1 Q969F0 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Intra
FATE1 Q969F0 NRG4 Homo sapiens Q8WWG1
Y2H Array
25416956
Intra
FATE1 Q969F0 NRG4 Homo sapiens Q8WWG1
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 DNAJC30 Homo sapiens Q96LL9
Validated Y2H
32296183
Intra
FATE1 Q969F0 TM4SF4 Homo sapiens P48230
Validated Y2H
25416956
Intra
FATE1 Q969F0 SEC22A Homo sapiens Q96IW7
Y2H Prey Pooling
25416956
Intra
FATE1 Q969F0 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra
FATE1 Q969F0 VSIG4 Homo sapiens Q9Y279
Validated Y2H
32296183
Intra
FATE1 Q969F0 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
Intra
FATE1 Q969F0 SLC38A1 Homo sapiens Q9H2H9
Y2H Array
25416956
Cross
FATE1 Q969F0 tax Human T-cell leukemia virus 1 P14079
MAPPIT
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Martin-Probst Syndrome

Deafness-Intellectual Disability, Martin-Probst Type Syndrome

Martin-Probst Deafness-Mental Retardation Syndrome

Mental Retardation, X-Linked, Syndromic, Martin-Probst Type

MRXSMP

Deafness-Intellectual Disability Syndrome, Martin-Probst Type

Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type

X-Linked Deafness-Intellectual Disability Syndrome Syndrome

X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04764 FATE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FATE1 VGNC VGNC:28878
Felis catus FATE1 VGNC VGNC:62160
Mus musculus FATE1 MGD MGI:1925155
Canis familiaris FATE1 VGNC VGNC:40746