IGSF8 - immunoglobulin superfamily member 8 Gene

Homo sapiens

Also known as EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1

Gene ID: 93185 | Gene type: protein coding

About IGSF8

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,091,339-160,099,468 (from NCBI)

This gene has 5 transcripts (splice variants), 170 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 17.6), skin (RPKM 9.6) and 24 other tissues.

Summary

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral Infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

IGSF8 Products(3)

mRNA	Protein	Name
NM_001206665.2	NP_001193594.1	immunoglobulin superfamily member 8 precursor
NM_001320247.2	NP_001307176.1	immunoglobulin superfamily member 8 precursor
NM_052868.6	NP_443100.1	immunoglobulin superfamily member 8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11504738	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	17785435	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	17785435	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	11504738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGSF8 Protein Structure

V-set

0
100
200
300
400
500
613 a.a.

Protein Preferred Names

Protein Names

immunoglobulin superfamily member 8

CD81 partner 3

Recombinant IGSF8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72736	CD316/IGSF8 Protein, Human (HEK293, His)	Q969P0-1 (R28-T579)	≥95%

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06651	IGSF8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IGSF8	RGD	RGD:1311500
Mus musculus	IGSF8	MGD	MGI:2154090
Canis familiaris	IGSF8	VGNC	VGNC:41918
Bos taurus	IGSF8	VGNC	VGNC:30096
Felis catus	IGSF8	VGNC	VGNC:62897
Macaca mulatta	IGSF8	VGNC	VGNC:73615
Others	IGSF8	NCBI

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