TCEAL1 - transcription elongation factor A like 1 Gene

Homo sapiens

Also known as p21; SIIR; WEX9; pp21

Gene ID: 9338 | Gene type: protein coding

About TCEAL1

Cytogenetic location: Xq22.2 Genomic coordinates (GRCh38): X:103,628,716-103,630,953 (from NCBI)

This gene has 4 transcripts (splice variants), 82 orthologues and 8 paralogues. Ubiquitous expression in ovary (RPKM 48.1), endometrium (RPKM 41.3) and 24 other tissues.

Summary

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with Other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

TCEAL1 Products(3)

mRNA	Protein	Name
NM_001006639.2	NP_001006640.1	transcription elongation factor A protein-like 1
NM_001006640.2	NP_001006641.1	transcription elongation factor A protein-like 1
NM_004780.3	NP_004771.2	transcription elongation factor A protein-like 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	7971997	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCEAL1 Protein Structure

BEX

0
100
159 a.a.

Protein Preferred Names

Protein Names

transcription elongation factor A protein-like 1

TCEA-like protein 1

TCEAL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TCEAL1	Q15170	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
Intra	TCEAL1	Q15170	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Hypomaturation Type, Iia3

Amelogenesis Imperfecta Hypomaturation Type 2a3	AI2A3
Amelogenesis Imperfecta Hypomaturation Type Iia3	Amelogenesis Imperfecta, Type Iia3
Amelogenesis Imperfecta Type Iia3	Amelogenesis Imperfecta, Hypomaturation Type, 2a3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14294	TCEAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TCEAL1	VGNC	VGNC:66017
Canis familiaris	TCEAL1	VGNC	VGNC:49659
Bos taurus	TCEAL1	VGNC	VGNC:49978
Macaca mulatta	TCEAL1	VGNC	VGNC:78282
Mus musculus	TCEAL1	MGD	MGI:2385317
Rattus norvegicus	TCEAL1	RGD	RGD:1549724

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