TPTE2 - transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Gene

Homo sapiens

Also known as TPIP

Gene ID: 93492 | Gene type: protein coding

About TPTE2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,422,877-19,561,574 (from NCBI)

This gene has 11 transcripts (splice variants), 185 orthologues and 6 paralogues. Restricted expression toward testis (RPKM 4.7).

Summary

TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol Phospholipids.[supplied by OMIM, Jul 2002]

TPTE2 Products(5)

mRNA	Protein	Name
NM_001141968.2	NP_001135440.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform delta
NM_001271850.2	NP_001258779.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform C2
NM_001395978.1	NP_001382907.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform gamma
NM_130785.4	NP_570141.3	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform alpha
NM_199254.3	NP_954863.2	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform gamma

TPTE2 Protein Structure

Ion_trans

DSPc

PTEN_C2

0
100
200
300
400
522 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

PTEN-like inositol lipid phosphatase

Related Diseases

Diseases

Alias

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14958	TPTE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TPTE2	MGD	MGI:2446460
Rattus norvegicus	TPTE2	RGD	RGD:1305825

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