ACP4 - acid phosphatase 4 Gene

Homo sapiens

Also known as ACPT; AI1J

Gene ID: 93650 | Gene type: protein coding

About ACP4

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,790,415-50,795,219 (from NCBI)

This gene has 1 transcript (splice variant), 159 orthologues, 5 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

Acid phosphatases are Enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate Cancer cell line. This gene exhibits a lower level of expression in testicular Cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

ACP4 Products(1)

mRNA	Protein	Name
NM_033068.3	NP_149059.1	testicular acid phosphatase precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	15219672	GOA
enables receptor tyrosine kinase binding	IDA IDA: Inferred from direct assay	15219672	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	15219672	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	15219672	GOA
involved in negative regulation of protein processing	IMP IMP: Inferred from mutant phenotype	15219672	GOA
involved in odontogenesis	IMP IMP: Inferred from mutant phenotype	27843125	GOA
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IDA IDA: Inferred from direct assay	15219672	GOA
involved in regulation of neuronal synaptic plasticity	IDA IDA: Inferred from direct assay	15219672	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACP4 Protein Structure

His_Phos_2

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

testicular acid phosphatase

acid phosphatase, testicular

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Type Ij

AI1J	Amelogenesis Imperfecta, Type 1j
Amelogenesis Imperfecta Type 1j	Amelogenesis Imperfecta 1j

Hypoplastic Amelogenesis Imperfecta

Amelogenesis Imperfecta Type 1	Amelogenesis Imperfecta, Hypoplastic Type
Amelogenesis Imperfecta Local Hypoplastic Form

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Congenital Bile Acid Synthesis Defect

3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency	Cba
Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency	Basd
Bile Acid Synthesis Defect, Congenital, 1

Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C	XPC
Xpcc	Xeroderma Pigmentosum Iii
Xp3	Xeroderma Pigmentosum Group C
Xp Group C	Xp, Group C
Xeroderma Pigmentosum, Type 3	Xeroderma Pigmentosum Complementation Group C
XP-C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00189	ACP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ACP4	VGNC	VGNC:52175
Macaca mulatta	ACP4	VGNC	VGNC:69396
Mus musculus	ACP4	MGD	MGI:3644563
Felis catus	ACP4	VGNC	VGNC:59526
Canis familiaris	ACP4	VGNC	VGNC:53522
Rattus norvegicus	ACP4	RGD	RGD:1308270
Others	ACP4	NCBI

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