2. Gene
  3. CADPS2 - calcium dependent secretion activator 2 Gene

CADPS2 - calcium dependent secretion activator 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAPS2

Gene ID: 93664 | Gene type: protein coding

About CADPS2

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:122,318,411-122,886,460 (from NCBI)

This gene has 6 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in kidney (RPKM 9.9), brain (RPKM 7.6) and 23 other tissues.

Summary

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

CADPS2 Products(15)

mRNA Protein Name
NM_001009571.4 NP_001009571.2 calcium-dependent secretion activator 2 isoform b
NM_001167940.2 NP_001161412.1 calcium-dependent secretion activator 2 isoform c
NM_001363389.2 NP_001350318.1 calcium-dependent secretion activator 2 isoform d
NM_001363390.2 NP_001350319.1 calcium-dependent secretion activator 2 isoform e
NM_001363391.2 NP_001350320.1 calcium-dependent secretion activator 2 isoform f
NM_001363392.2 NP_001350321.1 calcium-dependent secretion activator 2 isoform g
NM_001363393.2 NP_001350322.1 calcium-dependent secretion activator 2 isoform h
NM_001363394.2 NP_001350323.1 calcium-dependent secretion activator 2 isoform i
NM_001363395.2 NP_001350324.1 calcium-dependent secretion activator 2 isoform j
NM_001363396.2 NP_001350325.1 calcium-dependent secretion activator 2 isoform k
NM_001363397.2 NP_001350326.1 calcium-dependent secretion activator 2 isoform l
NM_001363398.2 NP_001350327.1 calcium-dependent secretion activator 2 isoform m
NM_001363399.2 NP_001350328.1 calcium-dependent secretion activator 2 isoform n
NM_001363400.2 NP_001350329.1 calcium-dependent secretion activator 2 isoform o
NM_017954.11 NP_060424.9 calcium-dependent secretion activator 2 isoform a

CADPS2 Protein Structure

PH

PH: PH domain (489 - 588)

DUF1041

DUF1041: Domain of Unknown Function (DUF1041) (800 - 894)

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  • 1296 a.a.
Protein Preferred Names Protein Names

calcium-dependent secretion activator 2

CAPS-2

Related Diseases

Diseases Alias
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Intellectual Developmental Disorder, X-Linked 108

MRX108

X-Linked Intellectual Developmental Disorder 108

Mental Retardation, X-Linked 108

Mental Retardation, X-Linked, Type 108
Mullegama-Klein-Martinez Syndrome

MKMS

Nedxcf

Neurodevelopmental Disorder, X-Linked, With Craniofacial Abnormalities

X-Linked Neurodevelopmental Disorder With Craniofacial Abnormalities
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01824 CADPS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CADPS2 VGNC VGNC:38659
Bos taurus CADPS2 VGNC VGNC:26699
Macaca mulatta CADPS2 VGNC VGNC:70564
Rattus norvegicus CADPS2 RGD RGD:1559440
Felis catus CADPS2 VGNC VGNC:60316
Mus musculus CADPS2 MGD MGI:2443963