NRXN3 - neurexin 3 Gene

Homo sapiens

Also known as C14orf60

Gene ID: 9369 | Gene type: protein coding

About NRXN3

Cytogenetic location: 14q24.3-q31.1 Genomic coordinates (GRCh38): 14:78,170,373-79,868,291 (from NCBI)

This gene has 19 transcripts (splice variants), 222 orthologues, 35 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 7.1), adrenal (RPKM 1.0) and 11 other tissues.

Summary

This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]

NRXN3 Products(7)

mRNA	Protein	Name
NM_001105250.3	NP_001098720.1	neurexin 3 isoform 3 precursor
NM_001272020.2	NP_001258949.1	neurexin 3 isoform 4 precursor
NM_001330195.2	NP_001317124.1	neurexin 3 isoform 5
NM_001366425.1	NP_001353354.1	neurexin 3 isoform 6
NM_001366426.1	NP_001353355.1	neurexin 3 isoform 7
NM_004796.6	NP_004787.2	neurexin 3 isoform 1
NM_138970.5	NP_620426.2	neurexin 3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adult behavior	IGI IGI: Inferred from genetic interaction	22209245	GOA
involved in learning	IGI IGI: Inferred from genetic interaction	22209245	GOA
involved in social behavior	IGI IGI: Inferred from genetic interaction	22209245	GOA
involved in vocalization behavior	IGI IGI: Inferred from genetic interaction	22209245	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRXN3 Protein Structure

Laminin_G_2

Syndecan

0
100
200
300
400
500
600
637 a.a.

Protein Preferred Names

Protein Names

neurexin 3

neurexin III

Recombinant NRXN3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75945	NRXN3/Neurexin-3 Protein, Human (HEK293, Fc)	Q9HDB5-2 (S36-T357)	≥95%
HY-P75946	NRXN3/Neurexin-3 Protein, Human (HEK293, His)	Q9HDB5-1 (S36-L357)	≥95%

Related Diseases

Diseases

Alias

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Borderline Personality Disorder

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Pitt-Hopkins-Like Syndrome 2

PTHSL2	Mesh
D006985	Mesh
D008607

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome	CDFES
PTHSL1	Cdfe Syndrome
Pitt-Hopkins Like Syndrome 1	Pitt-Hopkins-Like Syndrome-1
Cntnap2-Related Developmental And Epileptic Encephalopathy	Cntnap2-Related Dee
Mesh	D006985
Mesh	D008607

Childhood Disintegrative Disease

Childhood Disintegrative Disorder	Disintegrative Psychosis
Heller'S Syndrome	Symbiotic Psychosis
Dementia Infantilis	Heller Syndrome
Shared Paranoid Disorder

Tic Disorder

Tics	Behavioral Tic

Intellectual Developmental Disorder, X-Linked 108

MRX108	X-Linked Intellectual Developmental Disorder 108
Mental Retardation, X-Linked 108	Mental Retardation, X-Linked, Type 108

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Echolalia

Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome	22q13.3 Deletion Syndrome
Telomeric 22q13 Monosomy Syndrome	PHMDS
Deletion 22q13 Syndrome	22q13.3 Deletion
Deletion 22q13.3 Syndrome	Monosomy 22q13
Monosomy 22q13.3	22q13 Deletion Syndrome
Monosomy 22q13 Syndrome	22q13 Deletion
Chromosome Deletion

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Tobacco Addiction

Nicotine Dependence	Tobacco Addiction, Susceptibility To
Nicotine Addiction	Tobacco Use Disorder
Smoking Habit	Nicotine Dependence, Protection Against
Nicotine Addiction, Protection From	Cigarette Habituation
Cigarette Habituation, Susceptibility To	Smoking Habit, Susceptibility To
Nicotine Dependence, Susceptibility To	Nicotine Addiction, Susceptibility To
Addiction, Tobacco, Susceptibility To	Compulsive Tobacco User Syndrome
Tobacco Dependence	Tobacco Dependence Syndrome
Cigarette Addiction	Cigarette Dependence
Smoking Addiction	Smokers Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Specific Developmental Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09585	NRXN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NRXN3	VGNC	VGNC:104573
Rattus norvegicus	NRXN3	RGD	RGD:620212
Macaca mulatta	NRXN3	VGNC	VGNC:75535
Mus musculus	NRXN3	MGD	MGI:1096389
Others	NRXN3	NCBI

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